UFD1 and TIAM2

Data Source:
BioGRID (two hybrid)

		UFD1	TIAM2
Description		ubiquitin recognition factor in ER associated degradation 1	TIAM Rac1 associated GEF 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex	Cytosol Membrane Lamellipodium Filopodium Growth Cone Perikaryon Synapse Extracellular Exosome
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding	GTPase Activator Activity
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Lipid Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Translesion Synthesis by POLH Ub-specific processing proteases	NRAGE signals death through JNK Rho GTPase cycle PPARA activates gene expression G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 31361310) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Heel bone mineral density ( 30598549) Lipoprotein (a) levels ( 26377243) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP	9 interacting genes: ANXA7 DISC1 DNM2 H2AX PARD3 SH3GL2 TK1 TNIK UFD1
Entrez ID		7353	26230
HPRD ID		06778	05273
Ensembl ID		ENSG00000070010	ENSG00000146426
Uniprot IDs		Q541A5 Q92890	B3KW11 Q8IVF5
PDB IDs		2YUJ 5B6C 5C1B
Enriched GO Terms of Interacting Partners?
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