TIAM2 and ANXA7

Data Source:
BioGRID (two hybrid)

		TIAM2	ANXA7
Description		TIAM Rac1 associated GEF 2	annexin A7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Lamellipodium Filopodium Growth Cone Perikaryon Synapse Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Membrane Chromaffin Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	GTPase Activator Activity	RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Lipid Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	Autophagy Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion
Pathways		NRAGE signals death through JNK Rho GTPase cycle PPARA activates gene expression G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 31361310) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Heel bone mineral density ( 30598549) Lipoprotein (a) levels ( 26377243) Triiodothyronine levels and thyroxine levels ( 30843173)	Copper levels ( 26025379)
Interacting Genes		9 interacting genes: ANXA7 DISC1 DNM2 H2AX PARD3 SH3GL2 TK1 TNIK UFD1	107 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		26230	310
HPRD ID		05273	01720
Ensembl ID		ENSG00000146426	ENSG00000138279
Uniprot IDs		B3KW11 Q8IVF5	B2R657 P20073
PDB IDs
Enriched GO Terms of Interacting Partners?
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