UFD1 and GZMK

Data Source:
BioGRID (enzymatic study)

		UFD1	GZMK
Description		ubiquitin recognition factor in ER associated degradation 1	granzyme K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex	Extracellular Region
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process	Proteolysis
Pathways		Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488)
Interacting Genes		23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP	13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP
Entrez ID		7353	3003
HPRD ID		06778	02872
Ensembl ID		ENSG00000070010	ENSG00000113088
Uniprot IDs		Q541A5 Q92890	P49863
PDB IDs		2YUJ 5B6C 5C1B	1MZA 1MZD
Enriched GO Terms of Interacting Partners?
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