UFD1 and NUB1

Data Source:
BioGRID (pull down)

		UFD1	NUB1
Description		ubiquitin recognition factor in ER associated degradation 1	negative regulator of ubiquitin like proteins 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex	Nucleoplasm Nucleolus Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding	Protein Binding
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Interferon-gamma Response To Tumor Necrosis Factor Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS			Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)
Interacting Genes		23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP	12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP
Entrez ID		7353	51667
HPRD ID		06778	07450
Ensembl ID		ENSG00000070010	ENSG00000013374
Uniprot IDs		Q541A5 Q92890	A0A090N8Q5 H3BM14 H3BM74 Q9Y5A7
PDB IDs		2YUJ 5B6C 5C1B	1WJU
Enriched GO Terms of Interacting Partners?
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