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UBE2N and CCNB1
Data Source:
BioGRID
(enzymatic study)
UBE2N
CCNB1
Description
ubiquitin conjugating enzyme E2 N
cyclin B1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
UBC13-MMS2 Complex
Protein-containing Complex
UBC13-UEV1A Complex
Extracellular Exosome
Cyclin-dependent Protein Kinase Holoenzyme Complex
Spindle Pole
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Centrosome
Cytosol
Membrane
Cyclin B1-CDK1 Complex
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Patched Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin-like Protein Ligase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Activation Of MAPK Activity
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
JNK Cascade
Protein Ubiquitination
Histone Ubiquitination
Positive Regulation Of Histone Modification
Regulation Of Histone Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Oocyte Maturation
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase II Promoter
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Spindle Organization
Mitotic Nuclear Envelope Disassembly
Mitotic Metaphase Plate Congression
Spermatogenesis
Response To Mechanical Stimulus
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of MRNA 3'-end Processing
Positive Regulation Of Histone Phosphorylation
Tissue Regeneration
Response To Drug
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Cell Cycle
Response To DDT
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Development
Cell Division
Regulation Of Cell Cycle
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Chromosome Condensation
Protein-containing Complex Assembly
Cellular Response To Iron(III) Ion
Cellular Response To Fatty Acid
Cellular Response To Organic Cyclic Compound
Cellular Response To Hypoxia
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Pathways
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Depolymerisation of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
115 interacting genes:
AMFR
ARIH1
ARIH2
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DZIP3
F12
HERC2
HSP90AA1
LNX1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF165
RNF167
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TRIM14
TRIM17
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM32
TRIM33
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM69
TRIM72
UBA1
UBB
UBC
UBE2V1
UBE2V2
UBE3A
UHRF1
XIAP
ZNRF1
ZNRF2
ZNRF3
ZNRF4
59 interacting genes:
ANAPC11
ARID4A
BRCA1
CCNB1IP1
CCNF
CDC20
CDC25A
CDC25C
CDC27
CDC34
CDC6
CDK1
CDKN1A
CDKN1B
CDT1
EP300
FLNA
FZR1
GADD45A
GADD45B
GADD45G
H1-1
H1-5
HERC5
ITPR1
KAT5
MAP4
MEF2C
MOK
OTUD7B
PBK
PCNA
PIN1
PKMYT1
PLK1
POLA1
PRC1
PRKDC
PRKN
PTCH1
PTMA
RALBP1
RB1
RPA1
RUNX2
SQSTM1
TGFBR2
TP53BP1
TP73
TSC1
TSPYL2
TULP3
UBE2C
UBE2D2
UBE2N
UBE2S
UBE3C
UBE3D
XIAP
Entrez ID
7334
891
HPRD ID
04725
00454
Ensembl ID
ENSG00000177889
ENSG00000134057
Uniprot IDs
P61088
V9HW41
P14635
PDB IDs
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6P5B
6S53
6ULH
6UMP
6UMS
7BXG
2B9R
2JGZ
4Y72
4YC3
5HQ0
5LQF
6GU2
6GU3
6GU4
Enriched GO Terms of Interacting Partners
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