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UBE2N and RIPK1
Data Source:
BioGRID
(enzymatic study)
UBE2N
RIPK1
Description
ubiquitin conjugating enzyme E2 N
receptor interacting serine/threonine kinase 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
UBC13-MMS2 Complex
Protein-containing Complex
UBC13-UEV1A Complex
Extracellular Exosome
Mitochondrion
Cytosol
Plasma Membrane
Endosome Membrane
Death-inducing Signaling Complex
Protein-containing Complex
Receptor Complex
Membrane Raft
Ripoptosome
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
Death Receptor Binding
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Death Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Activation Of MAPK Activity
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
JNK Cascade
Protein Ubiquitination
Histone Ubiquitination
Positive Regulation Of Histone Modification
Regulation Of Histone Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Positive Regulation Of Protein Phosphorylation
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Cell Death
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Necrotic Cell Death
Viral Process
Protein Deubiquitination
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
Peptidyl-serine Autophosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Protein Catabolic Process
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Positive Regulation Of Inflammatory Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Positive Regulation Of Interleukin-6-mediated Signaling Pathway
T Cell Apoptotic Process
Necroptotic Process
Cellular Response To Hydrogen Peroxide
Regulation Of ATP:ADP Antiporter Activity
Cellular Response To Tumor Necrosis Factor
Death-inducing Signaling Complex Assembly
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Ripoptosome Assembly
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Hydrogen Peroxide-induced Cell Death
Amyloid Fibril Formation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Caspase activation via Death Receptors in the presence of ligand
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Ub-specific processing proteases
Ovarian tumor domain proteases
Dimerization of procaspase-8
TNF signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IKK complex recruitment mediated by RIP1
Potential therapeutics for SARS
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Drugs
Fostamatinib
Diseases
GWAS
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Cerebral white matter volume (
31530798
)
Depressive symptoms x independent stressful life events interaction (1df test) (
30718454
)
Depressive symptoms x independent stressful life events interaction (2df test) (
30718454
)
Idiopathic osteonecrosis of the femoral head (
28000841
)
Interacting Genes
115 interacting genes:
AMFR
ARIH1
ARIH2
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DZIP3
F12
HERC2
HSP90AA1
LNX1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF165
RNF167
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TRIM14
TRIM17
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM32
TRIM33
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM69
TRIM72
UBA1
UBB
UBC
UBE2V1
UBE2V2
UBE3A
UHRF1
XIAP
ZNRF1
ZNRF2
ZNRF3
ZNRF4
45 interacting genes:
BIRC3
CASP8
CCDC50
CDC42BPB
CFLAR
CRADD
EGFR
FADD
FAS
HSP90AA1
IKBKB
IKBKE
IKBKG
ITCH
MAP3K14
MAP3K3
MAP3K8
MTDH
NFKB1
NUMBL
OTUD1
PELI1
PTK2
RIPK3
RNF11
RNF216
SQSTM1
TAX1BP1
TBK1
TICAM1
TNF
TNFAIP3
TNFRSF10A
TNFRSF10B
TNFRSF1A
TRADD
TRAF1
TRAF2
TRAF3
TRAF5
TRIM38
TRPC4AP
UBE2N
YOD1
ZFAND5
Entrez ID
7334
8737
HPRD ID
04725
04583
Ensembl ID
ENSG00000177889
ENSG00000137275
Uniprot IDs
P61088
V9HW41
A0A024QZU0
Q13546
PDB IDs
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6P5B
6S53
6ULH
6UMP
6UMS
7BXG
4ITH
4ITI
4ITJ
4NEU
5HX6
5TX5
5V7Z
6AC5
6C3E
6C4D
6HHO
6NW2
6NYH
6OCQ
6R5F
6RLN
Enriched GO Terms of Interacting Partners
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