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UBE2N and RFFL
Data Source:
BioGRID
(pull down)
UBE2N
RFFL
Description
ubiquitin conjugating enzyme E2 N
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
UBC13-MMS2 Complex
Protein-containing Complex
UBC13-UEV1A Complex
Extracellular Exosome
Golgi Membrane
Nucleoplasm
Cytoplasm
Lysosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Recycling Endosome Membrane
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Protease Binding
P53 Binding
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Activation Of MAPK Activity
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
JNK Cascade
Protein Ubiquitination
Histone Ubiquitination
Positive Regulation Of Histone Modification
Regulation Of Histone Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Ubiquitin-protein Transferase Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Regulation Of Fibroblast Migration
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of TOR Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of TP53 Degradation
Drugs
Diseases
GWAS
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Acute post-radiotherapy pain in breast cancer (
31196165
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Night sleep phenotypes (
27126917
)
QT interval (
19305408
)
Interacting Genes
115 interacting genes:
AMFR
ARIH1
ARIH2
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DZIP3
F12
HERC2
HSP90AA1
LNX1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF165
RNF167
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TRIM14
TRIM17
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM32
TRIM33
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM69
TRIM72
UBA1
UBB
UBC
UBE2V1
UBE2V2
UBE3A
UHRF1
XIAP
ZNRF1
ZNRF2
ZNRF3
ZNRF4
21 interacting genes:
ATXN3
ATXN3L
EHD1
ESPL1
MICALL1
OPTN
OTUB1
OTUB2
RAB11FIP1
SFN
STAM
UBE2D1
UBE2D2
UBE2D3
UBE2G2
UBE2N
UBE2V2
UCHL5
USP28
USP5
USP7
Entrez ID
7334
117584
HPRD ID
04725
11489
Ensembl ID
ENSG00000177889
ENSG00000092871
Uniprot IDs
P61088
V9HW41
Q8WZ73
PDB IDs
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6P5B
6S53
6ULH
6UMP
6UMS
7BXG
1Y02
Enriched GO Terms of Interacting Partners
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