RFFL and ATXN3L

Data Source:
BioGRID (enzymatic study)

		RFFL	ATXN3L
Description		ring finger and FYVE like domain containing E3 ubiquitin protein ligase	ataxin 3 like
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane	Nucleus Cytosol
	Molecular Function	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Deubiquitination Protein Phosphopantetheinylation
Pathways		Regulation of TP53 Degradation	Josephin domain DUBs
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)	Bipolar disorder ( 31043756)
Interacting Genes		21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7	8 interacting genes: KLF5 PJA1 RFFL TRIM54 TRIM55 TRIM63 UBC USP28
Entrez ID		117584	92552
HPRD ID		11489	19697
Ensembl ID		ENSG00000092871	ENSG00000123594
Uniprot IDs		Q8WZ73	B4DYC7 Q9H3M9
PDB IDs		1Y02	3O65
Enriched GO Terms of Interacting Partners?
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