RFFL and RAB11FIP1

Data Source:
BioGRID (enzymatic study)

		RFFL	RAB11FIP1
Description		ring finger and FYVE like domain containing E3 ubiquitin protein ligase	RAB11 family interacting protein 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane	Cytosol Phagocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Transport Regulated Exocytosis Negative Regulation Of Adiponectin Secretion
Pathways		Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)	Axial length ( 24144296)
Interacting Genes		21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7	5 interacting genes: RAB11A RAB11B RAB25 RAB4A RFFL
Entrez ID		117584	80223
HPRD ID		11489	09787
Ensembl ID		ENSG00000092871	ENSG00000156675
Uniprot IDs		Q8WZ73	Q6WKZ4
PDB IDs		1Y02	4D0G
Enriched GO Terms of Interacting Partners?
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