C8B and C8A

Data Source:
HPRD (in vitro, in vivo)

		C8B	C8A
Description		complement C8 beta chain	complement C8 alpha chain
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GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Membrane Extracellular Exosome Extracellular Vesicle	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Protein-containing Complex Binding	Complement Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation
Pathways		Terminal pathway of complement Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate	Zinc Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 29875488 28240269) Logical memory (delayed recall) in normal cognition ( 29274321)	Blood protein levels ( 28240269)
Interacting Genes		3 interacting genes: C5 C8A CLU	9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1
Entrez ID		732	731
HPRD ID		00410	00409
Ensembl ID		ENSG00000021852	ENSG00000157131
Uniprot IDs		B7Z550 B7Z555 P07358	P07357
PDB IDs		3OJY 6H03 6H04	2QOS 2QQH 2RD7 3OJY 6H03 6H04
Enriched GO Terms of Interacting Partners?
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