C8A and C8B

Data Source:
HPRD (in vitro, in vivo)

		C8A	C8B
Description		complement C8 alpha chain	complement C8 beta chain
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GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Membrane Attack Complex Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	Complement Binding Protein Binding Protein-containing Complex Binding	Protein-containing Complex Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation
Pathways		Terminal pathway of complement Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Zinc acetate	Zinc Copper Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 28240269)	Blood protein levels ( 29875488 28240269) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1	3 interacting genes: C5 C8A CLU
Entrez ID		731	732
HPRD ID		00409	00410
Ensembl ID		ENSG00000157131	ENSG00000021852
Uniprot IDs		P07357	B7Z550 B7Z555 P07358
PDB IDs		2QOS 2QQH 2RD7 3OJY 6H03 6H04	3OJY 6H03 6H04
Enriched GO Terms of Interacting Partners?
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