UBE2J2 and HERC4

Data Source:
BioGRID (pull down)

		UBE2J2	HERC4
Description		ubiquitin conjugating enzyme E2 J2	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Fibrillar Center Cytosol
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity
	Biological Process	Protein Polyubiquitination Response To Unfolded Protein Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Positive Regulation Of Protein Targeting To Mitochondrion	Spermatogenesis Protein Ubiquitination Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)	Body mass index ( 28892062)
Interacting Genes		21 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MDM2 MGRN1 NEDD4L PRKN RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP	6 interacting genes: HERC6 UBC UBE2D2 UBE2E3 UBE2J2 UBE2L3
Entrez ID		118424	26091
HPRD ID		15600	13646
Ensembl ID		ENSG00000160087	ENSG00000148634
Uniprot IDs		A0A024R075 A6NGS0 Q8N2K1	A0A024QZN8 Q5GLZ8
PDB IDs		2F4W
Enriched GO Terms of Interacting Partners?
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