UBB and IKBKB

Data Source:
HPRD (in vivo)

		UBB	IKBKB
Description		ubiquitin B	inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Endocytic Vesicle Membrane Vesicle Neuron Projection Neuronal Cell Body Host Cell Extracellular Exosome	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Protein Targeting To Peroxisome Male Meiosis I Female Meiosis I Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Female Gonad Development Wnt Signaling Pathway Endosomal Transport Protein Ubiquitination Protein Deubiquitination Viral Life Cycle Virion Assembly Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process Translesion Synthesis Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Nucleotide-excision Repair, DNA Incision TRIF-dependent Toll-like Receptor Signaling Pathway Interstrand Cross-link Repair Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mitochondrion Transport Along Microtubule Neuron Projection Morphogenesis Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Mitochondrial Membrane Potential Transmembrane Transport Fat Pad Development Membrane Organization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Global Genome Nucleotide-excision Repair Error-free Translesion Synthesis Seminiferous Tubule Development Intracellular Transport Of Virus Energy Homeostasis Regulation Of Neuron Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Monoubiquitination	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Peptidyl-serine Phosphorylation Cortical Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Myosin-light-chain-phosphatase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport Circadian Clock TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Maturation of protein E Maturation of protein E Negative regulation of FLT3 FLT3 signaling by CBL mutants TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs		(4s)-5-Fluoro-L-Leucine	Mesalazine Sulfasalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321)
Interacting Genes		81 interacting genes: APP ATXN3 BIRC2 BRAP BRCA1 CDC25A CDC34 CDIP1 CDKN1B CDT1 CDX2 CHEK1 DAZAP2 DESI1 DNMT1 DUSP1 ECT2 EGFR ELF4 EPS15 ERBB2 FANCD2 FSHR HDAC6 HGS HLA-A IKBKB IKBKG JUN LIG4 LYN MAPT MDM2 MTURN MYBL2 MYC NR3C1 NTRK1 NTRK2 OPTN PCNA PIN1 PLEKHB2 PLSCR4 POLI PRKN PSMD4 RABGEF1 RAD23A RAD23B RNF11 SDCBP SH3KBP1 SKP2 SMAD4 SMURF1 SNCA SNCAIP SQSTM1 STUB1 SYK TAX1BP1 TGFBR1 TP53 TRAF6 TRIM37 TRIM5 UBAC1 UBASH3A UBASH3B UBE2D2 UBE2K UBE2N UBE2S UBQLN1 UBQLN2 UIMC1 USP1 USP30 WWOX XIAP	87 interacting genes: ACVR1 AKT1 AURKA CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB
Entrez ID		7314	3551
HPRD ID		06771	04462
Ensembl ID		ENSG00000170315	ENSG00000104365
Uniprot IDs		P0CG47 Q5U5U6	O14920
PDB IDs		2KHW 2MBB 2MRO 2MSG 2N13 4UEL 4UF6 4WHV 4WLR 4WUR 4XOF 4ZFR 4ZFT 4ZPZ 4ZUX 5BNB 5CAW 5CRA 5CVM 5CVN 5CVO 5D0K 5D0M 5DFL 5DK8 5E6J 5EDV 5EMZ 5EYA 5GJQ 5GO7 5GO8 5GOB 5GOC 5GOD 5GOG 5GOH 5GOI 5GOJ 5GOK 5H7S 5IBK 5IFR 5JBY 5JG6 5JP3 5JTJ 5JTV 5K9P 5KGF 5KHY 5KYC 5KYD 5KYE 5KYF 5L8H 5L8W 5L9T 5LN1 5LRV 5LRW 5LRX 5M93 5MNJ 5N2W 5N38 5NL5 5NLJ 5NVG 5O44 5O6T 5OHK 5OHL 5OHN 5OHP 5TOF 5TOG 5TUT 5TXK 5UJL 5UJN 5ULF 5ULH 5ULK 5V1Y 5V1Z 5VEY 5VF0 5VNZ 5VO0 5VZM 5VZW 5W46 5WFI 5X3M 5X3N 5X3O 5XBO 5XDP 5XK4 5XK5 5XPK 5YDR 5YIJ 5YIK 5YMY 5YT6 5ZBU 5ZD0 6ASR 6BVA 6BYH 6C16 6CP2 6DGF 6EI1 6FDK 6FGE 6FTX 6FX4 6FYH 6GLC 6GZS 6H4H 6HEI 6HEK 6IF1 6ISU 6JB6 6JB7 6JMA 6K4I 6K9P 6KOW 6KOX 6MSB 6MSD 6MSE 6MSG 6N13 6NJG 6O96 6OAM 6PGV 6QF8 6QK9 6QML 6TBM 6UH5 6XAA 7CAP 7JMS	3BRT 3BRV 4E3C 4KIK
Enriched GO Terms of Interacting Partners?
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