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TRAF1 and GATA2
Data Source:
BioGRID
(two hybrid)
TRAF1
GATA2
Description
TNF receptor associated factor 1
GATA binding protein 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
Plasma Membrane Signaling Receptor Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Molecular Function
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Apoptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JNK Cascade
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein-containing Complex Assembly
Protein K63-linked Ubiquitination
Regulation Of Extrinsic Apoptotic Signaling Pathway
Urogenital System Development
Cell Fate Determination
Neuron Migration
Embryonic Placenta Development
Regulation Of Transcription By RNA Polymerase II
Phagocytosis
Positive Regulation Of Cytosolic Calcium Ion Concentration
Blood Coagulation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Primitive Erythrocyte Differentiation
Ventral Spinal Cord Interneuron Differentiation
Cell Differentiation In Hindbrain
Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain
Central Nervous System Neuron Development
Pituitary Gland Development
Response To Lipid
Somatic Stem Cell Population Maintenance
Regulation Of Histone Acetylation
Eosinophil Fate Commitment
Inner Ear Morphogenesis
Positive Regulation Of Mast Cell Degranulation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Fate Commitment
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis, Engulfment
Definitive Hemopoiesis
Semicircular Canal Development
Vascular Wound Healing
Negative Regulation Of Fat Cell Proliferation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Cochlea Development
GABAergic Neuron Differentiation
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Neural Precursor Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Forebrain Neuron Differentiation
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30891314
24782177
23143596
24390342
20453842
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
White blood cell count (
32888494
)
Basophil count (
28031487
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Diastolic blood pressure (
30578418
)
Eosinophil counts (
19198610
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
27863252
)
Plateletcrit (
32888494
)
Preterm birth (maternal effect) (
28877031
)
Prostate cancer (
31562322
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
)
White blood cell count (
21738480
)
White blood cell count (basophil) (
28158719
)
White blood cell count (eosinophil) (
28158719
)
White blood cell types (
21738478
)
Interacting Genes
245 interacting genes:
A1CF
ABHD17A
ACTN3
AKAP17A
AQP1
ARID5A
ARNT2
ARSJ
BARD1
BCAS2
BCL6
BEX2
BEX3
BIRC2
BIRC3
C1orf109
C1orf216
C2CD6
C4orf45
CARHSP1
CASP10
CASP3
CASP6
CASP8
CCDC116
CCDC120
CCDC146
CCDC185
CCDC187
CCDC198
CCHCR1
CD40
CDCA3
CDK18
CDKN1A
CDKN2B
CFLAR
CHCHD3
COX5B
CRACR2A
CRY2
CRYGA
CYB5R2
DEPTOR
DGCR6
DMRT3
DOK3
DUSP13
DUSP21
DUSP4
EBF2
EDAR
EHHADH
ENKD1
EWSR1
FAM161A
FAM161B
FAM86C1P
FBF1
FBXL18
FOSL2
GADD45GIP1
GATA1
GATA2
GATAD2B
GCA
GCM2
GEM
GFI1B
GIT2
GLIS3
GLRX3
GMCL2
GNG5
GOLGA2
GORASP2
GRAP2
HAUS1
HELT
HEY2
HGS
HIVEP3
HMG20B
HNRNPM
HOXA1
HOXB5
HOXC8
HOXD12
IKBKB
JOSD1
KANK2
KIAA1217
KIF1A
KLHL38
KPNA2
KRT3
KRT75
LATS1
LCOR
LIN37
LMNTD2
LNX1
LNX2
LRRN1
LTBR
MACIR
MAP3K14
MAP6
MAPRE2
MATR3
METTL17
MORN3
MOS
MSGN1
MYEF2
MYOZ1
NEBL
NOL4L-DT
NTAQ1
NUFIP2
NUP58
OLIG3
PATZ1
PBX3
PDE4D
PHF21A
PIN1
PITX1
PITX2
PKN1
PLAC8
PLEKHN1
POM121L4P
POP5
PPP1R13B
PPP1R32
PRDM7
PRKAB2
PSMA1
PSMB1
QRICH1
RASAL2
RASSF5
RBCK1
RBM41
RBM45
RCOR3
RIIAD1
RIPK1
RIPK2
RIPOR3
RIPPLY1
RNF31
RTP5
SAMD11
SCNM1
SDCBP2
SH3GLB2
SHARPIN
SHC3
SHFL
SIK3
SLC25A48
SLC25A6
SNRNP25
SNW1
SOHLH1
SPATA46
SPG21
SPOP
SRC
SSC5D
STK3
SUMO2
SYCE1
TANK
TBC1D16
TBC1D8
TBX18
TCEA2
TCF7L2
TCL1A
TEAD4
TFAP2D
TFAP4
TFPT
THAP7
TICAM1
TIFA
TLE5
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF9
TRADD
TRAF2
TRAF3IP2
TRAF6
TRAIP
TRIM23
TRIM37
TRIM42
TRPV6
TSHZ2
TSSC4
USP2
USP7
UTP14C
VEZF1
WAC
ZBTB1
ZBTB16
ZC2HC1C
ZFYVE21
ZFYVE26
ZIC1
ZNF124
ZNF20
ZNF23
ZNF250
ZNF417
ZNF440
ZNF490
ZNF502
ZNF512B
ZNF564
ZNF572
ZNF581
ZNF587
ZNF627
ZNF648
ZNF662
ZNF669
ZNF688
ZNF697
ZNF844
46 interacting genes:
ADAMTSL4
AKT1
CDK1
CEBPA
CYSRT1
EP300
FBXW7
FHL3
GOLGA2
HDAC3
HDAC5
HHEX
JUN
KAT2A
KRT40
KRTAP10-3
KRTAP10-9
KRTAP11-1
KRTAP13-3
KRTAP21-2
KRTAP3-1
KRTAP6-3
KRTAP7-1
KRTAP8-1
LMO2
MAPK1
MDFI
MSX2
NOTCH2NLA
PML
POU1F1
POU2AF1
PRR20A
PSMA3
RARA
RBPMS
RXRA
SMAD4
SPI1
STAT3
TAL1
TRAF1
TRIM23
ZBTB16
ZBTB32
ZFPM1
Entrez ID
7185
2624
HPRD ID
03418
00673
Ensembl ID
ENSG00000056558
ENSG00000179348
Uniprot IDs
Q13077
P23769
PDB IDs
3M0D
5E1T
5H10
5O9B
Enriched GO Terms of Interacting Partners
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