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TRAF1 and TRIM23
Data Source:
BioGRID
(two hybrid)
TRAF1
TRIM23
Description
TNF receptor associated factor 1
tripartite motif containing 23
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoplasmic Side Of Plasma Membrane
Plasma Membrane Signaling Receptor Complex
Golgi Membrane
Nucleus
Cytoplasm
Lysosomal Membrane
Plasma Membrane
Molecular Function
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
GTPase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
GTP Binding
Enzyme Activator Activity
Zinc Ion Binding
GDP Binding
Identical Protein Binding
Biological Process
Apoptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JNK Cascade
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein-containing Complex Assembly
Protein K63-linked Ubiquitination
Regulation Of Extrinsic Apoptotic Signaling Pathway
Intracellular Protein Transport
Viral Process
Vesicle-mediated Transport
Protein Ubiquitination
Innate Immune Response
Regulation Of Catalytic Activity
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30891314
24782177
23143596
24390342
20453842
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
White blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
245 interacting genes:
A1CF
ABHD17A
ACTN3
AKAP17A
AQP1
ARID5A
ARNT2
ARSJ
BARD1
BCAS2
BCL6
BEX2
BEX3
BIRC2
BIRC3
C1orf109
C1orf216
C2CD6
C4orf45
CARHSP1
CASP10
CASP3
CASP6
CASP8
CCDC116
CCDC120
CCDC146
CCDC185
CCDC187
CCDC198
CCHCR1
CD40
CDCA3
CDK18
CDKN1A
CDKN2B
CFLAR
CHCHD3
COX5B
CRACR2A
CRY2
CRYGA
CYB5R2
DEPTOR
DGCR6
DMRT3
DOK3
DUSP13
DUSP21
DUSP4
EBF2
EDAR
EHHADH
ENKD1
EWSR1
FAM161A
FAM161B
FAM86C1P
FBF1
FBXL18
FOSL2
GADD45GIP1
GATA1
GATA2
GATAD2B
GCA
GCM2
GEM
GFI1B
GIT2
GLIS3
GLRX3
GMCL2
GNG5
GOLGA2
GORASP2
GRAP2
HAUS1
HELT
HEY2
HGS
HIVEP3
HMG20B
HNRNPM
HOXA1
HOXB5
HOXC8
HOXD12
IKBKB
JOSD1
KANK2
KIAA1217
KIF1A
KLHL38
KPNA2
KRT3
KRT75
LATS1
LCOR
LIN37
LMNTD2
LNX1
LNX2
LRRN1
LTBR
MACIR
MAP3K14
MAP6
MAPRE2
MATR3
METTL17
MORN3
MOS
MSGN1
MYEF2
MYOZ1
NEBL
NOL4L-DT
NTAQ1
NUFIP2
NUP58
OLIG3
PATZ1
PBX3
PDE4D
PHF21A
PIN1
PITX1
PITX2
PKN1
PLAC8
PLEKHN1
POM121L4P
POP5
PPP1R13B
PPP1R32
PRDM7
PRKAB2
PSMA1
PSMB1
QRICH1
RASAL2
RASSF5
RBCK1
RBM41
RBM45
RCOR3
RIIAD1
RIPK1
RIPK2
RIPOR3
RIPPLY1
RNF31
RTP5
SAMD11
SCNM1
SDCBP2
SH3GLB2
SHARPIN
SHC3
SHFL
SIK3
SLC25A48
SLC25A6
SNRNP25
SNW1
SOHLH1
SPATA46
SPG21
SPOP
SRC
SSC5D
STK3
SUMO2
SYCE1
TANK
TBC1D16
TBC1D8
TBX18
TCEA2
TCF7L2
TCL1A
TEAD4
TFAP2D
TFAP4
TFPT
THAP7
TICAM1
TIFA
TLE5
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF9
TRADD
TRAF2
TRAF3IP2
TRAF6
TRAIP
TRIM23
TRIM37
TRIM42
TRPV6
TSHZ2
TSSC4
USP2
USP7
UTP14C
VEZF1
WAC
ZBTB1
ZBTB16
ZC2HC1C
ZFYVE21
ZFYVE26
ZIC1
ZNF124
ZNF20
ZNF23
ZNF250
ZNF417
ZNF440
ZNF490
ZNF502
ZNF512B
ZNF564
ZNF572
ZNF581
ZNF587
ZNF627
ZNF648
ZNF662
ZNF669
ZNF688
ZNF697
ZNF844
218 interacting genes:
ACTN4
AKTIP
ANKRD36BP1
ANKRD55
AP3M1
AQP1
ARFGAP1
ARHGEF3
ARNT2
ATPAF2
ATXN7
BAG1
BAZ2B
BICRAL
BRME1
C2CD6
C8orf33
CARD9
CBX8
CCDC13
CCDC146
CCDC25
CCDC33
CDC20B
CDC73
CDR2
CFAP53
CHP1P2
COX5B
CPNE7
CREB5
CSRP2
CWF19L2
CXCL14
CYTH1
CYTH2
DCX
DEPP1
DMC1
DMRT3
DNAAF4
DOCK2
EAF2
EHHADH
EIF3D
ENKD1
EPN2
EXOC3-AS1
FAM110A
FAM133A
FAM193B
FAM83A
FAM90A1
FBF1
FHIT
FLAD1
FXR2
GAD1
GATA2
GCC2-AS1
GEM
GGA2
GGA3
GLIDR
GMCL2
GPANK1
GPKOW
HAPLN2
HAUS1
HGS
HNRNPLL
HOXB5
HSPB7
IL16
IQCE
IQUB
JOSD1
JRK
KAT5
KIFC3
KLHL42
KRT6A
KRT75
KRT76
LAGE3
LENG1
LGALS14
LGALS3
LGALS8
LINC00526
LINC01018
LMO2
LMO3
LNX1
MDM2
MKRN3
MLH1
MORN4
MRPL4
MRPL45
MSRB3
MTFR2
MYEF2
MYOM1
MYOZ1
NAB2
NEDD9
NEK6
NFU1
NOXA1
NTAQ1
NUDT21
NXT2
PDE4D
PHF1
PIAS2
PIK3R2
PITX1
PKP4
PLEKHA2
POLI
POLL
POM121
PPIL2
PPP1R15B
PPP1R18
PRPF18
PRPF31
PSMA1
PSMB1
RAD18
RAMAC
RCAN3
RIBC1
RIBC2
RIN1
RNF126
RNF213
RNF32
RNF34
RNF6
RSRC2
RTP5
RUFY1
SCNM1
SF1
SH2D4A
SIAH1
SIRPA
SLC25A6
SMG9
SNAI1
SNAI2
SNRPB
SNRPB2
SNW1
SORBS3
SPG21
STK19
SUMO1P1
TACO1
TASOR2
TBC1D22B
TCEA2
TCEANC
TEPSIN
TEX33
TMSB4X
TNFAIP3
TRAF1
TRAIP
TRIM27
TRIM29
TRIM31
TRIM32
TRIM42
TRIM55
TRIM63
TROAP
TSEN54
TSG101
TSHZ3
TXNDC5
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
UBE2W
UBOX5
UBQLN1
USP2
USP20
USP21
UTP23
VGLL1
WDR25
ZBTB16
ZBTB4
ZC2HC1C
ZFAND2A
ZNF20
ZNF250
ZNF408
ZNF417
ZNF474
ZNF564
ZNF581
ZNF587
ZNF688
ZNF835
Entrez ID
7185
373
HPRD ID
03418
03449
Ensembl ID
ENSG00000056558
ENSG00000113595
Uniprot IDs
Q13077
P36406
PDB IDs
3M0D
5E1T
5H10
5VZV
5VZW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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