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TPM1 and NOD2
Data Source:
BioGRID
(two hybrid)
TPM1
NOD2
Description
tropomyosin 1
nucleotide binding oligomerization domain containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Cytosol
Cytoskeleton
Muscle Thin Filament Tropomyosin
Actin Filament
Actin Cytoskeleton
Sarcomere
Bleb
Ruffle Membrane
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Vesicle
Protein-containing Complex
Phagocytic Vesicle
Anchored Component Of Plasma Membrane
Molecular Function
Actin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Actin Filament Binding
Actin Binding
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Hsp70 Protein Binding
Muramyl Dipeptide Binding
Pattern Recognition Receptor Activity
Peptidoglycan Binding
Protein-containing Complex Binding
CARD Domain Binding
Hsp90 Protein Binding
Biological Process
Positive Regulation Of Heart Rate By Epinephrine
Muscle Contraction
Regulation Of Muscle Contraction
Cytoskeleton Organization
Actin Filament Organization
Regulation Of Heart Contraction
Regulation Of Cell Shape
Muscle Filament Sliding
Negative Regulation Of Cell Migration
Ruffle Organization
Positive Regulation Of ATPase Activity
Cellular Response To Reactive Oxygen Species
Wound Healing
Sarcomere Organization
Positive Regulation Of Cell Adhesion
Positive Regulation Of Stress Fiber Assembly
Ventricular Cardiac Muscle Tissue Morphogenesis
Cardiac Muscle Contraction
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Activation Of MAPK Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response In Mucosa
Activation Of Immune Response
Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of T Cell Mediated Immunity
Positive Regulation Of Dendritic Cell Cytokine Production
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Defense Response
Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria
JNK Cascade
Response To Nutrient
Detection Of Biotic Stimulus
Detection Of Bacterium
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Detection Of Muramyl Dipeptide
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-18 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Intracellular Signal Transduction
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Oxidoreductase Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Xenophagy
Negative Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways
Striated Muscle Contraction
Smooth Muscle Contraction
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Drugs
Artenimol
Phenethyl Isothiocyanate
Mifamurtide
Diseases
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy (DCM)
Blau syndrome
Crohn's disease
GWAS
Apolipoprotein A1 levels (
32203549
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31451708
)
HDL cholesterol levels (
32203549
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Hemoglobin (
32888494
)
Impaired insulin sensitivity in response to n-3 PUFA supplementation (
31779001
)
Mean platelet volume (
19820697
32888494
27863252
)
Orofacial clefts (
22863734
)
Parkinson's disease (
32201043
)
Parkinson's disease (familial, age at onset) (
27402877
)
Platelet count (
22139419
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Pulse pressure (
27841878
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32203549
)
Asthma (
31361310
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
20570966
22936669
22412388
17554300
21102463
23128233
17804789
)
Inflammatory bowel disease (
18758464
28067908
)
Leprosy (
20018961
27976721
25642632
)
Medication use (thyroid preparations) (
31015401
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Interacting Genes
33 interacting genes:
ACTB
BLOC1S6
C1orf216
CAGE1
CCDC96
CCHCR1
CDC42
CLIP4
EGFR
EPB41
FAM9C
FGA
GOLGA2
IFIT3
JUN
KXD1
MAD1L1
MAST2
NEB
NOD2
PKD2
PSMC5
S100A2
SNAPIN
SYCE1
TFPT
TMOD2
TNNT1
TNNT2
TPM2
TPM4
WASHC1
YEATS4
38 interacting genes:
ALPI
ANKHD1
ANXA2
ATG16L1
C10orf67
CCL13
CHMP4B
CHMP5
DCTN1
DOCK7
ENTR1
ERBIN
GOLGA6L5P
GOLGB1
HAP1
IKBIP
IRGM
LDOC1
LMNA
LURAP1L
MAP3K7
NLRC4
PDLIM5
PPP1R12C
PPP2R3B
PRR16
RIPK2
RPL13A
SCYL1
TACC3
TNIP1
TPM1
TPM3
TPM4
TRIM41
VCP
WBP11
XIAP
Entrez ID
7168
64127
HPRD ID
01839
05810
Ensembl ID
ENSG00000140416
ENSG00000167207
Uniprot IDs
A0A024R5W6
A0A0K0K1I0
B7Z596
B7Z722
D9YZV4
D9YZV5
D9YZV7
F5H7S3
H0YK48
H7BYY1
O15513
P09493
A0A286YF65
Q9HC29
PDB IDs
3MUD
5KHT
6UT2
6X5Z
Enriched GO Terms of Interacting Partners
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