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NOD2 and ERBIN
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, two hybrid)
NOD2
ERBIN
Description
nucleotide binding oligomerization domain containing 2
erbb2 interacting protein
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Vesicle
Protein-containing Complex
Phagocytic Vesicle
Anchored Component Of Plasma Membrane
Basement Membrane
Nucleus
Cytoplasm
Plasma Membrane
Basal Plasma Membrane
Basolateral Plasma Membrane
Nuclear Speck
Cell Junction
Hemidesmosome
Nuclear Membrane
Postsynapse
Glutamatergic Synapse
Molecular Function
Actin Binding
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Hsp70 Protein Binding
Muramyl Dipeptide Binding
Pattern Recognition Receptor Activity
Peptidoglycan Binding
Protein-containing Complex Binding
CARD Domain Binding
Hsp90 Protein Binding
Signaling Receptor Binding
ErbB-2 Class Receptor Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Biological Process
Activation Of MAPK Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response In Mucosa
Activation Of Immune Response
Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of T Cell Mediated Immunity
Positive Regulation Of Dendritic Cell Cytokine Production
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Defense Response
Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria
JNK Cascade
Response To Nutrient
Detection Of Biotic Stimulus
Detection Of Bacterium
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Detection Of Muramyl Dipeptide
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-18 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Intracellular Signal Transduction
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Oxidoreductase Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Xenophagy
Negative Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Prostaglandin-E Synthase Activity
Protein Targeting
Cell Adhesion
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
ERBB2 Signaling Pathway
Intermediate Filament Cytoskeleton Organization
Basal Protein Localization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Signaling by ERBB2
Downregulation of ERBB2 signaling
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Mifamurtide
Diseases
Blau syndrome
Crohn's disease
GWAS
Asthma (
31361310
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
20570966
22936669
22412388
17554300
21102463
23128233
17804789
)
Inflammatory bowel disease (
18758464
28067908
)
Leprosy (
20018961
27976721
25642632
)
Medication use (thyroid preparations) (
31015401
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Interacting Genes
38 interacting genes:
ALPI
ANKHD1
ANXA2
ATG16L1
C10orf67
CCL13
CHMP4B
CHMP5
DCTN1
DOCK7
ENTR1
ERBIN
GOLGA6L5P
GOLGB1
HAP1
IKBIP
IRGM
LDOC1
LMNA
LURAP1L
MAP3K7
NLRC4
PDLIM5
PPP1R12C
PPP2R3B
PRR16
RIPK2
RPL13A
SCYL1
TACC3
TNIP1
TPM1
TPM3
TPM4
TRIM41
VCP
WBP11
XIAP
66 interacting genes:
ABCA1
ABCC4
ABR
ACTN1
ACTN2
ACVR2A
ACVR2B
AGTR2
APC
ARHGEF7
ARVCF
ATP2B1
ATP2B2
ATP2B4
BANF1
CASK
CDH1
CHUK
COPB1
CTNNB1
CTNND1
CTNND2
CTSG
DLG4
DST
ERBB2
FOXO3
GRIN2B
GRIN2C
GUCY1A2
ITGB4
KCNA4
KCNA5
LAMB1
LMO1
LMO2
LRRC1
MAP4
MAPK12
MCC
MEF2A
MPP1
MPP2
MPP3
MUSK
NOD2
NR2E1
PICK1
PKP4
RAF1
RBX1
RNF7
RPS6KA1
SCN4A
SHOC2
SLC5A5
SLC5A6
SLC6A12
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
STAT3
VIPR2
ZFYVE9
Entrez ID
64127
55914
HPRD ID
05810
06090
Ensembl ID
ENSG00000167207
ENSG00000112851
Uniprot IDs
A0A286YF65
Q9HC29
Q96RT1
PDB IDs
1MFG
1MFL
1N7T
2H3L
2QBW
3CH8
6Q0M
6Q0N
6Q0U
6UBG
6UBH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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