TPM1 and TPM2

Data Source:
HPRD (in vivo, in vitro)

		TPM1	TPM2
Description		tropomyosin 1	tropomyosin 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane	Cytosol Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Muscle Contraction Actin Filament Organization Muscle Filament Sliding Regulation Of ATPase Activity
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Striated Muscle Contraction Smooth Muscle Contraction
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases		Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)	Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 19820697 32888494 27863252) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494 27863252) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)	Immature fraction of reticulocytes ( 32888494) Platelet count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		33 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCDC96 CCHCR1 CDC42 CLIP4 EGFR EPB41 FAM9C FGA GOLGA2 IFIT3 JUN KXD1 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4 WASHC1 YEATS4	22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785
Entrez ID		7168	7169
HPRD ID		01839	11768
Ensembl ID		ENSG00000140416	ENSG00000198467
Uniprot IDs		A0A024R5W6 A0A0K0K1I0 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H7BYY1 O15513 P09493	A7XZE4 P07951 Q5TCU3 V9HW25
PDB IDs		3MUD 5KHT 6UT2 6X5Z
Enriched GO Terms of Interacting Partners?
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