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NOD2 and HAP1
Data Source:
BioGRID
(two hybrid)
NOD2
HAP1
Description
nucleotide binding oligomerization domain containing 2
huntingtin associated protein 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Vesicle
Protein-containing Complex
Phagocytic Vesicle
Anchored Component Of Plasma Membrane
Nucleolus
Mitochondrion
Lysosome
Early Endosome
Autophagosome
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Cytoskeleton
Synaptic Vesicle
Actin Cytoskeleton
Inclusion Body
Dendrite
Growth Cone
Cytoplasmic Vesicle
Dendritic Spine
Axon Cytoplasm
Molecular Function
Actin Binding
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Hsp70 Protein Binding
Muramyl Dipeptide Binding
Pattern Recognition Receptor Activity
Peptidoglycan Binding
Protein-containing Complex Binding
CARD Domain Binding
Hsp90 Protein Binding
Signaling Receptor Binding
Protein Binding
Myosin Binding
Ion Channel Binding
Brain-derived Neurotrophic Factor Binding
Biological Process
Activation Of MAPK Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response In Mucosa
Activation Of Immune Response
Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of T Cell Mediated Immunity
Positive Regulation Of Dendritic Cell Cytokine Production
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Defense Response
Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria
JNK Cascade
Response To Nutrient
Detection Of Biotic Stimulus
Detection Of Bacterium
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Detection Of Muramyl Dipeptide
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-18 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Intracellular Signal Transduction
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Oxidoreductase Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Xenophagy
Negative Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Prostaglandin-E Synthase Activity
Protein Targeting
Exocytosis
Autophagy
Chemical Synaptic Transmission
Brain Development
Anterograde Axonal Transport
Retrograde Axonal Transport
Protein Localization
Regulation Of Exocytosis
Cerebellum Development
Hypothalamus Cell Differentiation
Neurogenesis
Cell Projection Organization
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Positive Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Neurotrophin TRK Receptor Signaling Pathway
Mitochondrion Distribution
Positive Regulation Of Neurogenesis
Anterograde Axonal Transport Of Mitochondrion
Negative Regulation Of Amyloid-beta Formation
Regulation Of Organelle Transport Along Microtubule
Positive Regulation Of Non-motile Cilium Assembly
Pathways
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Drugs
Mifamurtide
Diseases
Blau syndrome
Crohn's disease
GWAS
Asthma (
31361310
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
20570966
22936669
22412388
17554300
21102463
23128233
17804789
)
Inflammatory bowel disease (
18758464
28067908
)
Leprosy (
20018961
27976721
25642632
)
Medication use (thyroid preparations) (
31015401
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Developmental language disorder (syntactic complexity) (
27016271
)
Esophageal cancer (squamous cell) (
22960999
)
Interacting Genes
38 interacting genes:
ALPI
ANKHD1
ANXA2
ATG16L1
C10orf67
CCL13
CHMP4B
CHMP5
DCTN1
DOCK7
ENTR1
ERBIN
GOLGA6L5P
GOLGB1
HAP1
IKBIP
IRGM
LDOC1
LMNA
LURAP1L
MAP3K7
NLRC4
PDLIM5
PPP1R12C
PPP2R3B
PRR16
RIPK2
RPL13A
SCYL1
TACC3
TNIP1
TPM1
TPM3
TPM4
TRIM41
VCP
WBP11
XIAP
93 interacting genes:
AEN
ANTKMT
APLP1
ATP5MF
BARD1
BRD7
C1orf216
C2CD6
C7orf25
C8orf33
CBX8
CCDC113
CCDC13
CDC73
CDK18
CDK5RAP2
COL9A2
CRIP1
DCTN1
DDX49
DEFB1
EIF3E
FAM50B
FEZ1
GABARAPL2
GADD45G
GIT1
GPRASP2
HDAC4
HGS
HMOX2
HOXB5
HSPA1A
HSPA4
HTT
IMMT
ING5
KAT5
KAT7
KATNBL1
KBTBD7
KPNA2
LRIF1
LUC7L2
MPP3
MRPS9
MSGN1
NAP1L5
NDUFB9
NEUROD1
NIPSNAP3A
NOD2
NOP53
PABPC4
PCM1
PDCD7
PFDN1
PKN1
PPID
PPOX
PPP1R18
PRPF31
PSMD11
RER1
RHPN1
RIF1
RPS10
RPS25
SCNM1
SNAPIN
SRSF4
STX5
TAF1D
TBP
TIMM17A
TNNT1
TNNT3
TOMM20
TSPYL1
UTP3
VIM
ZFP1
ZMAT2
ZNF124
ZNF20
ZNF24
ZNF33B
ZNF490
ZNF572
ZNF575
ZNF648
ZNF691
ZNF835
Entrez ID
64127
9001
HPRD ID
05810
02972
Ensembl ID
ENSG00000167207
ENSG00000173805
Uniprot IDs
A0A286YF65
Q9HC29
P54257
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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