TPD52 and SOCS2

Data Source:
BioGRID (two hybrid)

		TPD52	SOCS2
Description		tumor protein D52	suppressor of cytokine signaling 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Calcium Ion Binding Protein Binding Protein Homodimerization Activity	Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Anatomical Structure Morphogenesis B Cell Differentiation Secretion	Regulation Of Cell Growth Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Protein Ubiquitination Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphatidylinositol Phosphorylation Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development
Pathways		Golgi Associated Vesicle Biogenesis	Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling
Drugs
Diseases
GWAS		Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31361310 31959851 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lapatinib-induced hepatotoxicity ( 25987243) Metabolite levels (HVA/MHPG ratio) ( 23319000) Metabolite levels (Pyroglutamine) ( 23934736) Rheumatoid arthritis ( 30423114 24390342) Self-reported allergy ( 23817569)	Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951 18391952) Hepatic lipid content in extreme obesity ( 25246029) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)
Interacting Genes		14 interacting genes: ANXA6 AR MAL2 SENP2 SH3GLB1 SOCS2 SPG21 SRPK2 STUB1 THAP4 TPD52L1 TPD52L2 TPD52L3 TTPA	19 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TPD52 YES1
Entrez ID		7163	8835
HPRD ID		04963	05490
Ensembl ID		ENSG00000076554	ENSG00000120833
Uniprot IDs		P55327	A0A024RBD2 O14508
PDB IDs			2C9W 4JGH 5BO4 6I4X 6I5J 6I5N
Enriched GO Terms of Interacting Partners?
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