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SOCS2 and PLA2G1B
Data Source:
BioGRID
(two hybrid)
SOCS2
PLA2G1B
Description
suppressor of cytokine signaling 2
phospholipase A2 group IB
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Phosphatidylinositol 3-kinase Complex
Extracellular Region
Extracellular Space
Cell Surface
Secretory Granule
Molecular Function
Growth Hormone Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
JAK Pathway Signal Transduction Adaptor Activity
1-phosphatidylinositol-3-kinase Regulator Activity
Phospholipase A2 Activity
Signaling Receptor Binding
Calcium Ion Binding
Bile Acid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process
Regulation Of Cell Growth
Receptor Signaling Pathway Via JAK-STAT
Lactation
Regulation Of Signal Transduction
Protein Ubiquitination
Response To Estradiol
Cellular Response To Hormone Stimulus
Intracellular Signal Transduction
Interleukin-7-mediated Signaling Pathway
Negative Regulation Of Multicellular Organism Growth
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Post-translational Protein Modification
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Phosphatidylinositol Phosphorylation
Growth Hormone Receptor Signaling Pathway
Mammary Gland Alveolus Development
Activation Of MAPK Activity
Innate Immune Response In Mucosa
Neutrophil Mediated Immunity
Fatty Acid Biosynthetic Process
Phosphatidic Acid Biosynthetic Process
Actin Filament Organization
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Lipid Catabolic Process
Leukotriene Biosynthetic Process
Antibacterial Humoral Response
Neutrophil Chemotaxis
Activation Of Phospholipase A2 Activity
Positive Regulation Of Interleukin-8 Production
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Glucose Import
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Positive Regulation Of Fibroblast Proliferation
Arachidonic Acid Secretion
Positive Regulation Of Protein Secretion
Positive Regulation Of Immune Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process
Pathways
Interleukin-7 signaling
Neddylation
Negative regulation of FLT3
Growth hormone receptor signaling
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Drugs
Sulfasalazine
Azelastine
Hexane-1,6-Diol
N-Tridecanoic Acid
Cholic Acid
P-Anisic Acid
Heptanoic acid
1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine
Pyruvaldehyde
Lpc-Ether
Niflumic acid
PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER
1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL
Medical Cannabis
Diseases
GWAS
Height (
28552196
20881960
25282103
25429064
23563607
31562340
18391951
18391952
)
Hepatic lipid content in extreme obesity (
25246029
)
Joint damage in rheumatoid arthritis (
31596875
)
Pubertal anthropometrics (
23449627
)
Type 2 diabetes (
30054458
)
Bipolar disorder (
31043756
)
Interacting Genes
19 interacting genes:
ARFIP2
BMI1
EGFR
EPOR
ERBB3
ERBB4
GHR
IGF1R
INSR
KIT
MET
PLA2G1B
PRLR
PTK2
RYBP
SOCS3
STK16
TPD52
YES1
5 interacting genes:
BGN
CSF3R
PLA2G2A
PLAA
SOCS2
Entrez ID
8835
5319
HPRD ID
05490
01396
Ensembl ID
ENSG00000120833
ENSG00000170890
Uniprot IDs
A0A024RBD2
O14508
P04054
PDB IDs
2C9W
4JGH
5BO4
6I4X
6I5J
6I5N
1YSK
3ELO
6Q42
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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