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SOCS2 and SOCS3
Data Source:
HPRD
(in vitro)
SOCS2
SOCS3
Description
suppressor of cytokine signaling 2
suppressor of cytokine signaling 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Phosphatidylinositol 3-kinase Complex
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Growth Hormone Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
JAK Pathway Signal Transduction Adaptor Activity
1-phosphatidylinositol-3-kinase Regulator Activity
Phosphotyrosine Residue Binding
Protein Kinase Inhibitor Activity
Protein Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Biological Process
Regulation Of Cell Growth
Receptor Signaling Pathway Via JAK-STAT
Lactation
Regulation Of Signal Transduction
Protein Ubiquitination
Response To Estradiol
Cellular Response To Hormone Stimulus
Intracellular Signal Transduction
Interleukin-7-mediated Signaling Pathway
Negative Regulation Of Multicellular Organism Growth
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Post-translational Protein Modification
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Phosphatidylinositol Phosphorylation
Growth Hormone Receptor Signaling Pathway
Mammary Gland Alveolus Development
Negative Regulation Of Protein Kinase Activity
Receptor Signaling Pathway Via JAK-STAT
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Regulation Of Growth
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Post-translational Protein Modification
Positive Regulation Of Cell Differentiation
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol Phosphorylation
Negative Regulation Of Inflammatory Response
Regulation Of Interferon-gamma-mediated Signaling Pathway
Branching Involved In Labyrinthine Layer Morphogenesis
Placenta Blood Vessel Development
Trophoblast Giant Cell Differentiation
Interleukin-6-mediated Signaling Pathway
Cellular Response To Leukemia Inhibitory Factor
Pathways
Interleukin-7 signaling
Neddylation
Negative regulation of FLT3
Growth hormone receptor signaling
Interleukin-6 signaling
Signaling by Leptin
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Neddylation
Interferon alpha/beta signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
28552196
20881960
25282103
25429064
23563607
31562340
18391951
18391952
)
Hepatic lipid content in extreme obesity (
25246029
)
Joint damage in rheumatoid arthritis (
31596875
)
Pubertal anthropometrics (
23449627
)
Type 2 diabetes (
30054458
)
Asthma (
32296059
)
Blood trace element (Se levels) (
23720494
)
Creatine kinase levels (
29403010
)
Interacting Genes
19 interacting genes:
ARFIP2
BMI1
EGFR
EPOR
ERBB3
ERBB4
GHR
IGF1R
INSR
KIT
MET
PLA2G1B
PRLR
PTK2
RYBP
SOCS3
STK16
TPD52
YES1
63 interacting genes:
ABL1
ACADVL
APP
AR
BCL10
BIK
BLK
CSF1R
CSF3R
CSNK1E
CUEDC2
CXCR4
EGFR
ELOB
ELOC
EPOR
ERBB2
ERBB3
ERBB4
GAB1
GFRA1
GHR
HIVEP1
IGF1R
IL12RB2
IL2RB
IL6ST
INSR
IRF7
IRS1
IRS2
JAK1
JAK2
JAK3
KIAA1958
KIT
LEPR
MAP1S
MAPK11
MAPK6
MET
NME4
PDPK1
PIN1
PPP3CB
PRLR
PTK2
PTPN11
RASA1
RBMX
RNF31
RNF7
RPL7A
SH2D2A
SOCS2
TES
TFDP1
TFR2
TRDN
TXK
TXNDC11
YES1
YWHAQ
Entrez ID
8835
9021
HPRD ID
05490
05006
Ensembl ID
ENSG00000120833
ENSG00000184557
Uniprot IDs
A0A024RBD2
O14508
O14543
Q6FI39
PDB IDs
2C9W
4JGH
5BO4
6I4X
6I5J
6I5N
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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