XPO1 and TERT

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		XPO1	TERT
Description		exportin 1	telomerase reverse transcriptase
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Plasma Membrane PML Body Nuclear Speck RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomerase RNA Reverse Transcriptase Activity RNA Binding RNA-directed DNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding Chaperone Binding Telomerase RNA Binding Template-free RNA Nucleotidyltransferase
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Biogenesis Regulation Of MRNA Stability MRNA Transport Intracellular Transport Of Virus	Telomere Maintenance Transcription, RNA-templated RNA-dependent DNA Biosynthetic Process Telomere Maintenance Via Telomerase Mitochondrion Organization Negative Regulation Of Gene Expression DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Regulation Of Protein Stability Positive Regulation Of Protein Binding Positive Regulation Of Hair Cycle Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Glucose Import Response To Cadmium Ion Positive Regulation Of Nitric-oxide Synthase Activity Double-stranded RNA Biosynthetic Process Establishment Of Protein Localization To Telomere Cellular Response To Hypoxia DNA Biosynthetic Process Replicative Senescence Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Transdifferentiation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Protein Localization To Nucleolus Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Beta-catenin-TCF Complex Assembly Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex
Drugs		Selinexor	Zidovudine Grn163l Tertomotide
Diseases			Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
GWAS		Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)	Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Basal cell carcinoma ( 31174203 19151717 24403052 25855136) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 24163127 20972438) Breast cancer ( 22037553 29059683 23535729 23535733 27117709 28171663) Breast cancer (estrogen-receptor negative) ( 27117709 28171663 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Cancer (pleiotropy) ( 27197191) Chronic lymphocytic leukemia ( 28165464 26956414) Chronic lymphocytic leukemia or systemic lupus erythematosus ( 31407831) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epithelial ovarian cancer ( 25581431) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 30714141 28346443 21827660 21531791 22886559 29743610 19578367) Glioma (high-grade) ( 24908248) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Idiopathic pulmonary fibrosis ( 31710517 18835860) Interstitial lung disease ( 23583980) Intrinsic epigenetic age acceleration ( 29374233) Keratinocyte cancer (MTAG) ( 31174203) Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 20700438 28604730 19836008 22797724 20871597 27393504) Lung cancer ( 21725308 23143601 27393504 18978790) Lung cancer in never smokers ( 31009812 28604730) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular volume ( 29403010 32888494 27863252 28017375) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Nasopharyngeal carcinoma ( 27436580 26545403) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Nevus count or cutaneous melanoma ( 30429480) Non-albumin protein levels ( 29403010) Non-glioblastoma glioma ( 28346443 29743610) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 29422604 27579533 25086665) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate cancer ( 31562322 21743467 25939597) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 29403010 32888494 20139978 27863252) Serum prostate-specific antigen levels ( 21160077) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Telomere length ( 24465473 29151059) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266) Uveal melanoma ( 28781888) White blood cell count ( 29403010 32888494 27863252)
Interacting Genes		80 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73	80 interacting genes: ABL1 ACAA2 AKT1 ANXA2 ATP5F1B BECN1 BRAF CBLC CCND2 CCNE1 CCT5 CDK4 CDK6 CDKN2A CDKN2B CIB1 DACH1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 FAAP24 FGFR4 FOXO3 FZR1 GLA GLIS2 GRM1 HSP90AA1 HSPA4 IREB2 MAP2K3 MAP2K5 MAP3K5 MCRS1 MDM2 MET MTOR MYC NCL NF2 NSD3 PABPC1 PBK PDGFRA PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RAF1 RASSF1 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SOX3 SOX4 SRC STEAP4 STK11 TEAD2 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ
Entrez ID		7514	7015
HPRD ID		03975	01754
Ensembl ID		ENSG00000082898	ENSG00000164362
Uniprot IDs		B3KWD0 O14980	O14746
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO	2BCK 4B18 4MNQ 5MEN 5MEO 5MEP 5MEQ 5MER 5UGW
Enriched GO Terms of Interacting Partners?
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