C1QC and C1QA

Data Source:
HPRD (in vitro)

		C1QC	C1QA
Description		complement C1q C chain	complement C1q A chain
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse	Extracellular Region Collagen Trimer Complement Component C1 Complex Synapse Collagen-containing Extracellular Matrix Postsynapse
	Molecular Function	Protein Binding	Amyloid-beta Binding Protein Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation Synapse Pruning	Microglial Cell Activation Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Aging Response To Iron Ion Viral Process Neuron Remodeling Regulation Of Complement Activation Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Blood protein levels ( 30072576 29875488)	Inflammatory biomarkers (multivariate analysis) ( 33110245)
Interacting Genes		6 interacting genes: C1QA C1QB FKBP2 PTX3 UBQLN2 ZNF534	28 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 SGTA SGTB SLC25A47 UBQLN1 UBQLN2
Entrez ID		714	712
HPRD ID		00395	00393
Ensembl ID		ENSG00000159189	ENSG00000173372
Uniprot IDs		A0A024RAA7 P02747	A0A024RAG6 P02745
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V
Enriched GO Terms of Interacting Partners?
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