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C1QA and APCS
Data Source:
HPRD
(in vitro)
C1QA
APCS
Description
complement C1q A chain
amyloid P component, serum
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Synapse
Collagen-containing Extracellular Matrix
Postsynapse
Extracellular Region
Extracellular Space
Nucleus
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Amyloid-beta Binding
Protein Binding
Complement Component C1q Complex Binding
Calcium Ion Binding
Protein Binding
Low-density Lipoprotein Particle Binding
Carbohydrate Binding
Identical Protein Binding
Virion Binding
Unfolded Protein Binding
Biological Process
Microglial Cell Activation
Complement Activation
Complement Activation, Classical Pathway
Cell-cell Signaling
Aging
Response To Iron Ion
Viral Process
Neuron Remodeling
Regulation Of Complement Activation
Innate Immune Response
Astrocyte Activation
Synapse Organization
Synapse Pruning
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Positive Regulation Of Neuron Death
Negative Regulation Of Acute Inflammatory Response
Protein Folding
Acute-phase Response
Complement Activation, Classical Pathway
Cellular Protein Metabolic Process
Negative Regulation By Host Of Viral Process
Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
Innate Immune Response
Negative Regulation Of Monocyte Differentiation
Negative Regulation Of Viral Entry Into Host Cell
Negative Regulation Of Viral Process
Chaperone-mediated Protein Complex Assembly
Negative Regulation Of Wound Healing
Negative Regulation Of Exo-alpha-sialidase Activity
Negative Regulation Of Glycoprotein Metabolic Process
Pathways
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Amyloid fiber formation
Drugs
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Zinc
Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside
Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane
BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
Copper
Zinc acetate
Diseases
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Blood protein levels (
30072576
29875488
28240269
)
C-reactive protein (
22939635
)
Interacting Genes
28 interacting genes:
APCS
BAG6
C1QB
C1QBP
C1QC
C1R
C1S
CD93
COL2A1
CR1
CRP
CSPG4
DCN
FN1
GNPNAT1
HIPK3
HRG
HSPB2
NLGN3
PIAS2
PPP1CA
PPP1CC
PTX3
SGTA
SGTB
SLC25A47
UBQLN1
UBQLN2
18 interacting genes:
ALX1
C1QA
C4BPA
CALU
COL4A1
COPS5
CRP
FCGR1A
FCGR2B
FCGR3A
FCGR3B
FN1
GK
GOT2
GRB2
HES1
LAMA1
TG
Entrez ID
712
325
HPRD ID
00393
00101
Ensembl ID
ENSG00000173372
ENSG00000132703
Uniprot IDs
A0A024RAG6
P02745
P02743
V9HWP0
PDB IDs
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
1GYK
1LGN
1SAC
2A3W
2A3X
2A3Y
2W08
3D5O
3KQR
4AVS
4AVT
4AVV
4AYU
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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