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C1QA and HRG
Data Source:
HPRD
(in vivo)
C1QA
HRG
Description
complement C1q A chain
histidine rich glycoprotein
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Synapse
Collagen-containing Extracellular Matrix
Postsynapse
Extracellular Region
Plasma Membrane
Cell Surface
Platelet Alpha Granule Lumen
Endolysosome
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Amyloid-beta Binding
Protein Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Zinc Ion Binding
Immunoglobulin Binding
Heme Binding
Heparan Sulfate Proteoglycan Binding
Metal Ion Binding
Biological Process
Microglial Cell Activation
Complement Activation
Complement Activation, Classical Pathway
Cell-cell Signaling
Aging
Response To Iron Ion
Viral Process
Neuron Remodeling
Regulation Of Complement Activation
Innate Immune Response
Astrocyte Activation
Synapse Organization
Synapse Pruning
Complement-mediated Synapse Pruning
Vertebrate Eye-specific Patterning
Positive Regulation Of Neuron Death
Angiogenesis
Platelet Degranulation
Positive Regulation Of Immune Response To Tumor Cell
Chemotaxis
Negative Regulation Of Cell Adhesion
Negative Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Regulation Of Platelet Activation
Negative Regulation Of Lamellipodium Assembly
Negative Regulation Of Endopeptidase Activity
Heme Transport
Negative Regulation Of Angiogenesis
Platelet Activation
Regulation Of Blood Coagulation
Negative Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Cell Adhesion Mediated By Integrin
Fibrinolysis
Positive Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Fungus
Cytolysis By Host Of Symbiont Cells
Positive Regulation Of Focal Adhesion Assembly
Negative Regulation Of Fibrinolysis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Blood Vessel Remodeling
Negative Regulation Of Endothelial Cell Chemotaxis
Pathways
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Platelet degranulation
Dissolution of Fibrin Clot
Drugs
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
Inherited thrombophilia
GWAS
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Activated partial thromboplastin time (
22703881
20303064
)
Blood protein levels (
29875488
28240269
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Neurological blood protein biomarker levels (
31320639
)
Refractive error (
32231278
)
Interacting Genes
28 interacting genes:
APCS
BAG6
C1QB
C1QBP
C1QC
C1R
C1S
CD93
COL2A1
CR1
CRP
CSPG4
DCN
FN1
GNPNAT1
HIPK3
HRG
HSPB2
NLGN3
PIAS2
PPP1CA
PPP1CC
PTX3
SGTA
SGTB
SLC25A47
UBQLN1
UBQLN2
15 interacting genes:
C1QA
C1QB
CHRD
CYSRT1
FCGR1A
FGA
FN1
PLG
PLSCR1
RABAC1
RCHY1
RGS20
SPRY1
THBS1
TNFRSF1A
Entrez ID
712
3273
HPRD ID
00393
00812
Ensembl ID
ENSG00000173372
ENSG00000113905
Uniprot IDs
A0A024RAG6
P02745
P04196
PDB IDs
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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