NME1 and NME3

Data Source:
HPRD (in vivo)

		NME1	NME3
Description		NME/NM23 nucleoside diphosphate kinase 1	NME/NM23 nucleoside diphosphate kinase 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Centrosome Cytosol Intermediate Filament Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding RNA Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Metabolic Process Endocytosis Lactation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Hippocampus Development Cell Differentiation Response To Testosterone Cellular Response To Drug Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Apoptotic Process Nucleobase-containing Small Molecule Interconversion
Pathways		Interconversion of nucleotide di- and triphosphates	Interconversion of nucleotide di- and triphosphates
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 31043756) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)
Interacting Genes		31 interacting genes: APEX1 AURKA CCND3 FBXO24 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME2 NME3 NME4 NTAQ1 NUTF2 PID1 POLR1C PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3	11 interacting genes: APP DESI1 HTR2A JAM2 NME1 NME2 SGTA SGTB UBQLN1 UBQLN2 UBQLN4
Entrez ID		4830	4832
HPRD ID		01131	03488
Ensembl ID		ENSG00000239672	ENSG00000103024
Uniprot IDs		A0A384MTW7 P15531	Q13232
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4	1ZS6
Enriched GO Terms of Interacting Partners?
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