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ENO1 and BCL6
Data Source:
BioGRID
(two hybrid)
ENO1
BCL6
Description
enolase 1
BCL6 transcription repressor
Image
GO Annotations
Cellular Component
Phosphopyruvate Hydratase Complex
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Membrane
M Band
Extracellular Exosome
Cell Cortex Region
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
Golgi Apparatus
Molecular Function
Magnesium Ion Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
RNA Binding
Phosphopyruvate Hydratase Activity
Protein Binding
Protein Homodimerization Activity
Cadherin Binding
GTPase Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Gluconeogenesis
Glycolytic Process
Response To Virus
Positive Regulation Of Plasminogen Activation
Negative Regulation Of Cell Growth
Regulation Of Vacuole Fusion, Non-autophagic
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Muscle Contraction
Canonical Glycolysis
Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Regulation Of Cytokine Production
Negative Regulation Of Cell-matrix Adhesion
Germinal Center Formation
Regulation Of Germinal Center Formation
Regulation Of Immune System Process
Negative Regulation Of B Cell Apoptotic Process
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Rho Protein Signal Transduction
Spermatogenesis
Protein Localization
Negative Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Actin Cytoskeleton Organization
B Cell Differentiation
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Histone Deacetylation
Negative Regulation Of Mast Cell Cytokine Production
Negative Regulation Of Rho Protein Signal Transduction
Type 2 Immune Response
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Regulation Of Memory T Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Cell Differentiation
Negative Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Isotype Switching To IgE Isotypes
Erythrocyte Development
Regulation Of Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Cellular Component Movement
Negative Regulation Of Mitotic Cell Cycle DNA Replication
Negative Regulation Of Cellular Senescence
Pathways
Glycolysis
Gluconeogenesis
Manipulation of host energy metabolism
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
FOXO-mediated transcription of cell death genes
Drugs
Zinc
Copper
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Hairy-cell leukemia
GWAS
Asthma (
30929738
)
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) (
23453885
)
Blood protein levels (
30072576
)
Feeling tense (
29500382
)
Platelet count (
32888494
)
Plateletcrit (
32888494
27863252
)
Tonsillectomy (
27182965
28928442
)
White blood cell count (
32888494
)
White blood cell count (basophil) (
27863252
)
Adverse response to drug (
30420678
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Allergic sensitization (
23817571
)
Asthma (
31959851
)
B cell non-Hodgkin lymphoma (
23749188
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Blood urea nitrogen levels (
29403010
)
Glucose homeostasis traits (
25524916
)
Granulocyte percentage of myeloid white cells (
27863252
)
Height (
31562340
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
PR interval (
23534349
)
Pulmonary function (smoking interaction) (
23284291
)
Renal function-related traits (BUN) (
22797727
)
Selective IgA deficiency (
27723758
)
Self-reported allergy (
23817569
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
25760438
)
Interacting Genes
59 interacting genes:
AGTPBP1
ALDOA
AMBP
ARID1B
BCL6
BHLHE40
BRCA1
CBX5
CHEK2
CLK1
COL14A1
CYSLTR2
DES
DUX4
FANCA
FHL1
FLNC
FYN
GLIS3
GRB2
HDAC1
HEMGN
HEY2
HK2
HSP90AB1
HSPA8
HSPB2
ITGB1
IVNS1ABP
KDM2A
LIG4
LINC01554
LONRF3
MCPH1
MED13
MYOC
NCOR1
P4HB
PAF1
PCNA
PLG
PPP2R5E
RXFP3
SERPING1
SET
SGCG
SNAPC3
SRC
SUMO2
SUMO4
TCAP
TEAD1
TERT
TRAPPC2
TTN
UPF2
YWHAQ
YWHAZ
ZBTB44
89 interacting genes:
ANKRD53
ARHGEF9
ARRDC3
ATP23
BCL11A
BCL6B
BCOR
BLZF1
C4orf45
C7orf31
C9orf24
CABP4
CDK19
CDK8
CFAP161
CFAP97D1
CHD3
CNOT2
CRBN
CREBBP
CTNNB1
CUTC
DVL2
ENO1
EP300
FBXO11
GATA1
GLRX3
GOLGA2
HDAC1
HDAC4
HDAC5
HDAC7
HDAC9
IHO1
IRF4
JUN
JUNB
JUND
KIFC3
KLHL12
KLHL20
KRTAP13-1
KRTAP13-2
KRTAP19-1
LIMS3
LIMS4
MAPK1
MDFI
MED17
MED6
MTA3
MTUS2
NCOR1
NCOR2
PBX4
PELI1
PFDN5
PIN1
PML
POF1B
PPARD
PPTC7
PRKD3
PSMB4
RAF1
REL
RUNX1T1
SIAH1
SIN3A
SP1
SPI1
SSX2IP
TEKT4
TFIP11
TLE5
TP53
TP53BP1
TRAF1
TRAF2
TRIB3
TWIST1
WDR83
WNK4
ZBTB16
ZBTB17
ZBTB7A
ZBTB7B
ZNHIT1
Entrez ID
2023
604
HPRD ID
01400
00180
Ensembl ID
ENSG00000074800
ENSG00000113916
Uniprot IDs
A0A024R4F1
P06733
B5B0A5
P41182
PDB IDs
2PSN
3B97
5JLZ
5LAX
5NI9
5NIG
5OCK
1R28
1R29
1R2B
2EN2
2EOS
2LCE
2YRM
3BIM
3E4U
3LBZ
4CP3
4U2M
5H7G
5H7H
5MW2
5MW6
5MWD
5N1X
5N1Z
5N20
5N21
5X4M
5X4N
5X4O
5X4P
5X4Q
5X9O
5X9P
6C3L
6C3N
6CQ1
6EW6
6EW7
6EW8
6TOF
6TOG
6TOH
6TOI
6TOJ
6TOK
6TOL
6TOM
6TON
6TOO
Enriched GO Terms of Interacting Partners
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