ACVR2B and INHBA

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		ACVR2B	INHBA
Description		activin A receptor type 2B	inhibin subunit beta A
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Activin A Complex Inhibin A Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Inhibin Binding Identical Protein Binding Protein-containing Complex Binding Type II Activin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis	G1/S Transition Of Mitotic Cell Cycle Ovarian Follicle Development Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Wounding Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Striatal Medium Spiny Neuron Differentiation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Interferon-gamma Production Activin Receptor Signaling Pathway Endodermal Cell Differentiation Negative Regulation Of Phosphorylation Odontogenesis Response To Drug Hemoglobin Biosynthetic Process Progesterone Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Roof Of Mouth Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol GABAergic Neuron Differentiation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP	Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS		Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)	Asthma ( 29273806) Cortisol levels (saliva) ( 28843169) Menarche (age at onset) ( 27182965 21102462 25231870) Parent of origin effect on language impairment (paternal) ( 24571439) Pit-and-Fissure caries ( 23470693)
Interacting Genes		21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1	13 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3
Entrez ID		93	3624
HPRD ID		04106	00929
Ensembl ID		ENSG00000114739	ENSG00000122641
Uniprot IDs		Q13705	A4D1W7 P08476
PDB IDs		2H62 2QLU 4FAO 5NGV 5NHR	1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V 4MID 5HLY 5HLZ
Enriched GO Terms of Interacting Partners?
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