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ACVR2B and MSTN
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
ACVR2B
MSTN
Description
activin A receptor type 2B
myostatin
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Protein-containing Complex
Receptor Complex
Activin Receptor Complex
Extracellular Space
Cytoplasm
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Activin Receptor Activity, Type II
Activin-activated Receptor Activity
Growth Factor Binding
Metal Ion Binding
Activin Binding
Signaling Receptor Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Heparin Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Lymphangiogenesis
Blood Vessel Remodeling
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Anterior/posterior Pattern Specification
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Retina Vasculature Development In Camera-type Eye
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cold-induced Thermogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Muscle Organ Development
Response To Heat
Response To Gravity
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Skeletal Muscle Atrophy
Negative Regulation Of Muscle Hypertrophy
Myoblast Migration Involved In Skeletal Muscle Regeneration
Response To Muscle Activity
Ovulation Cycle Process
Response To Testosterone
Negative Regulation Of Kinase Activity
Response To Estrogen
Response To Ethanol
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Insulin Receptor Signaling Pathway
Muscle Cell Cellular Homeostasis
Negative Regulation Of Skeletal Muscle Tissue Growth
Response To Electrical Stimulus
Negative Regulation Of Protein Kinase B Signaling
SMAD Protein Signal Transduction
Cellular Response To Dexamethasone Stimulus
Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation
Negative Regulation Of Satellite Cell Differentiation
Negative Regulation Of Myoblast Proliferation
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
FOXO-mediated transcription of cell cycle genes
Drugs
MYO-029
Diseases
Heterotaxy; Situs ambiguus
GWAS
Bitter beverage consumption (
31046077
)
Body size at age 10 (
32376654
)
Estimated glomerular filtration rate (
31152163
31015462
)
P wave duration (
24850809
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
21 interacting genes:
ACVR1B
BMP10
BMP2
BMP7
ERBIN
FBXO7
GDF11
GDF2
GDF5
IGSF1
INHBA
INHBB
INHBC
MSTN
NODAL
SNX1
SNX2
SNX6
SYNJ2BP
TDGF1
TGFBRAP1
6 interacting genes:
ACVR2B
APP
FSTL3
SGTA
TCAP
WFIKKN2
Entrez ID
93
2660
HPRD ID
04106
03474
Ensembl ID
ENSG00000114739
ENSG00000138379
Uniprot IDs
Q13705
O14793
Q53S46
PDB IDs
2H62
2QLU
4FAO
5NGV
5NHR
5F3B
5F3H
5NTU
5NXS
6UMX
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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