TRAT1 and LCP2

Data Source:
BioGRID (pull down)

		TRAT1	LCP2
Description		T cell receptor associated transmembrane adaptor 1	lymphocyte cytosolic protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite T Cell Receptor Complex Mitotic Spindle	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Receptor Recycling Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359)	Acne (severe) ( 24927181) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		13 interacting genes: BDKRB1 CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SEC22A SRC TRA TRB	48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		50852	3937
HPRD ID		05392	03362
Ensembl ID		ENSG00000163519	ENSG00000043462
Uniprot IDs		C9JF66 Q6PIZ9	Q13094
PDB IDs			1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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