TRAT1 and TRA

Data Source:
HPRD (in vivo)

		TRAT1	TRA
Description		T cell receptor associated transmembrane adaptor 1	T cell receptor alpha locus
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite T Cell Receptor Complex Mitotic Spindle	Integral Component Of Membrane Alpha-beta T Cell Receptor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding	Signaling Receptor Activity
	Biological Process	Negative Regulation Of Receptor Recycling Adaptive Immune Response Cellular Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Pathways		PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		13 interacting genes: BDKRB1 CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SEC22A SRC TRA TRB	15 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TRAT1 TRB TRD
Entrez ID		50852	6955
HPRD ID		05392	01736
Ensembl ID		ENSG00000163519
Uniprot IDs		C9JF66 Q6PIZ9
PDB IDs
Enriched GO Terms of Interacting Partners?
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