TCF3 and MEN1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TCF3	MEN1
Description		transcription factor 3	menin 1
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GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding	Four-way Junction DNA Binding Y-form DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein-macromolecule Adaptor Activity Protein N-terminus Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Nervous System Development B Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Histone Lysine Methylation Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Telomerase Activity Beta-catenin-TCF Complex Assembly
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs	Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Carcinoid Adrenal carcinoma Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Malignant islet cell carcinoma
GWAS		Hodgkin's lymphoma ( 29196614 24920014) Objective response to lithium treatment ( 26503763)	Urate levels ( 21768215)
Interacting Genes		67 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 TWIST2 UBE2I USF1	32 interacting genes: ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 HDAC1 HDAC2 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM
Entrez ID		6929	4221
HPRD ID		00918	00564
Ensembl ID		ENSG00000071564	ENSG00000133895
Uniprot IDs		A0A0A0MRB7 P15923 X6REB3	A0A024R5D2 A0A024R5E3 A0A5F9ZHS3 O00255 Q9GZQ5
PDB IDs		1HLH 2MH0 2YPA 2YPB 3U5V 6MGN	3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6WNH
Enriched GO Terms of Interacting Partners?
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