MEN1 and FOXN3

Data Source:
BioGRID (pull down, pull down)

		MEN1	FOXN3
Description		menin 1	forkhead box N3
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex	Chromatin Nucleus
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein-macromolecule Adaptor Activity Protein N-terminus Binding R-SMAD Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Histone Lysine Methylation Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Telomerase Activity Beta-catenin-TCF Complex Assembly	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Mitotic G2 DNA Damage Checkpoint Negative Regulation Of Transcription, DNA-templated Craniofacial Suture Morphogenesis
Pathways		Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation
Drugs
Diseases		Carcinoid Adrenal carcinoma Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Malignant islet cell carcinoma
GWAS		Urate levels ( 21768215)	Attention deficit hyperactivity disorder symptom score ( 27663945) Body mass index ( 28552196) Cerebrospinal fluid clusterin levels ( 26545630) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Idiopathic intracranial hypertension ( 29608535) Insular cortex volume ( 31530798) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty acid liver disease ( 31311600) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Pulse pressure ( 30224653) Small cell lung carcinoma ( 28604730) Smoking initiation (ever regular vs never regular) ( 30679032) Weight loss (gastric bypass surgery) ( 23643386)
Interacting Genes		32 interacting genes: ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 HDAC1 HDAC2 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM	4 interacting genes: EXOSC8 MEN1 MFHAS1 SRPK2
Entrez ID		4221	1112
HPRD ID		00564	07533
Ensembl ID		ENSG00000133895	ENSG00000053254
Uniprot IDs		A0A024R5D2 A0A024R5E3 A0A5F9ZHS3 O00255 Q9GZQ5	A0A024R6I1 O00409
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6WNH	6NCE 6NCM
Enriched GO Terms of Interacting Partners?
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