MEN1 and IQGAP1

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		MEN1	IQGAP1
Description		menin 1	IQ motif containing GTPase activating protein 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Axon Growth Cone Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Membrane Raft Extracellular Exosome
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein-macromolecule Adaptor Activity Protein N-terminus Binding R-SMAD Binding	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Histone Lysine Methylation Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Telomerase Activity Beta-catenin-TCF Complex Assembly	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Viral Process Cell Migration Regulation Of Actin Cytoskeleton Organization Negative Regulation Of GTPase Activity Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Focal Adhesion Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Glomerular Visceral Epithelial Cell Development Positive Regulation Of Dendrite Development Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Localization Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Neuron Projection Extension Response To Angiotensin
Pathways		Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation	Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Artenimol
Diseases		Carcinoid Adrenal carcinoma Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Malignant islet cell carcinoma
GWAS		Urate levels ( 21768215)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Chronic postoperative pain ( 31903573) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 28196072) Monocyte count ( 32888494) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)
Interacting Genes		32 interacting genes: ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 HDAC1 HDAC2 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM	38 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP YWHAQ
Entrez ID		4221	8826
HPRD ID		00564	04541
Ensembl ID		ENSG00000133895	ENSG00000140575
Uniprot IDs		A0A024R5D2 A0A024R5E3 A0A5F9ZHS3 O00255 Q9GZQ5	A0A024RC65 P46940
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6WNH	1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?
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