MEN1 and CTNNB1

Data Source:
BioGRID (pull down, pull down)

		MEN1	CTNNB1
Description		menin 1	catenin beta 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Cytosol Nuclear Matrix Cleavage Furrow Protein-containing Complex Histone Methyltransferase Complex	Euchromatin Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Beta-catenin Destruction Complex Protein-containing Complex Protein-DNA Complex Cell Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery Beta-catenin-TCF Complex Wnt Signalosome
	Molecular Function	Four-way Junction DNA Binding Y-form DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Protein-macromolecule Adaptor Activity Protein N-terminus Binding R-SMAD Binding	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding I-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Protein Phosphorylation Osteoblast Development DNA Repair Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Population Proliferation Response To UV Response To Gamma Radiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Binding Histone Lysine Methylation Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Telomerase Activity Beta-catenin-TCF Complex Assembly	Protein Polyubiquitination Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Positive Regulation Of Neuroblast Proliferation Cell Adhesion Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Viral Process Wnt Signaling Pathway Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Regulation Of Centriole-centriole Cohesion Response To Estradiol Positive Regulation Of Type I Interferon Production Negative Regulation Of Protein Sumoylation Adherens Junction Assembly Protein Localization To Cell Surface Hair Cell Differentiation Entry Of Bacterium Into Host Cell Detection Of Muscle Stretch Embryonic Skeletal Limb Joint Morphogenesis Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Fibroblast Proliferation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Endothelial Tube Morphogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Calcium Ion Import Cell-cell Adhesion Positive Regulation Of Core Promoter Binding Beta-catenin-TCF Complex Assembly Beta-catenin Destruction Complex Disassembly Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Neuron Projection Extension Regulation Of Protein Localization To Cell Surface Positive Regulation Of DNA-templated Transcription, Initiation
Pathways		Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling
Drugs			Urea
Diseases		Carcinoid Adrenal carcinoma Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT) Malignant islet cell carcinoma	Gastric cancer Colorectal cancer Endometrial Cancer Pilomatricoma; Epithelioma calcificans of Malherbe Thyroid cancer Hepatocellular carcinoma
GWAS		Urate levels ( 21768215)	Bone mineral density (hip) ( 27311723 19801982) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) High myopia ( 31816047) Lumbar spine bone mineral density ( 29499414) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		32 interacting genes: ASH2L CTNNB1 DAXX DBF4 ESR1 FANCD2 FOXN3 GFAP H3-4 HDAC1 HDAC2 IQGAP1 JUND KMT2A KMT2D MYC MYH9 NFKB1 NFKB2 POLR2B RBBP5 RELA RPA2 SIN3A SMAD1 SMAD3 SMAD5 SNW1 TCF3 TCF7L2 TP53 VIM	187 interacting genes: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARFGEF1 ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL6 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC34 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBIN ESR1 EZR FBXW2 FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B H1-2 HIF1A HNF1A HUWE1 IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAP3K2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKM PKP2 PLK1 PPM1A PRKCG PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RUVBL1 RUVBL2 RXRA SALL1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SMURF1 SOX1 SOX17 SP1 SPN SRC STUB1 TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIM33 TRIM55 TRIM63 TRIP10 TRRAP UBE2B UBE2D1 UBE2R2 UBE2S UBE3A UHRF2 USP2 USP9X ZFYVE9 ZIC3
Entrez ID		4221	1499
HPRD ID		00564	00286
Ensembl ID		ENSG00000133895	ENSG00000168036
Uniprot IDs		A0A024R5D2 A0A024R5E3 A0A5F9ZHS3 O00255 Q9GZQ5	A0A024R2Q3 B4DGU4 P35222
PDB IDs		3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8 4X5Y 4X5Z 5DB0 5DB1 5DB2 5DB3 5DD9 5DDA 5DDB 5DDC 5DDD 5DDE 5DDF 6B41 6BXH 6BXY 6BY8 6E1A 6O5I 6OPJ 6PKC 6WNH	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS 6M90 6M91 6M92 6M93 6M94 6O9B 6O9C 6WLX 6WNX
Enriched GO Terms of Interacting Partners?
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