STYX and INSRR

Data Source:
BioGRID (two hybrid)

		STYX	INSRR
Description		serine/threonine/tyrosine interacting protein	insulin receptor related receptor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Integral Component Of Plasma Membrane Insulin Receptor Complex Axon Receptor Complex
	Molecular Function	Pseudophosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity F-box Domain Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding Insulin Receptor Substrate Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Protein Binding Negative Regulation Of Catalytic Activity MAPK Export From Nucleus Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Regulation Of ERK1 And ERK2 Cascade	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Male Sex Determination Actin Cytoskeleton Reorganization Positive Regulation Of Kinase Activity Protein Autophosphorylation Cellular Response To Alkaline PH
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Prostate cancer ( 23535732)	Uric acid clearance ( 28095793)
Interacting Genes		24 interacting genes: AATK CARHSP1 EGFR EPHA2 EPHA3 EPHA7 EPHB6 ERBB2 ERBB3 ERBB4 FBXO7 FBXW7 IGF1R INSR INSRR KDR KIT LMTK2 MAPK1 MUSK PTK7 ROR1 ROR2 TEK	6 interacting genes: CTDSP2 ERBB2 INSR KRT27 MEOX2 STYX
Entrez ID		6815	3645
HPRD ID		10258	00976
Ensembl ID		ENSG00000198252	ENSG00000027644
Uniprot IDs		A0A024R641 Q8WUJ0	P14616
PDB IDs		2R0B
Enriched GO Terms of Interacting Partners?
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