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STYX and KIT
Data Source:
BioGRID
(two hybrid)
STYX
KIT
Description
serine/threonine/tyrosine interacting protein
KIT proto-oncogene, receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Receptor Complex
Molecular Function
Pseudophosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
F-box Domain Binding
Protease Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Protein Dephosphorylation
Negative Regulation Of Protein Binding
Negative Regulation Of Catalytic Activity
MAPK Export From Nucleus
Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process
Regulation Of ERK1 And ERK2 Cascade
MAPK Cascade
Activation Of MAPK Activity
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Dendritic Cell Cytokine Production
Mast Cell Chemotaxis
Regulation Of Transcription By RNA Polymerase II
Glycosphingolipid Metabolic Process
Inflammatory Response
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Spermatogenesis
Spermatid Development
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Visual Learning
Male Gonad Development
Positive Regulation Of Gene Expression
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Actin Cytoskeleton Reorganization
Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Pigmentation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Tongue Development
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Somatic Stem Cell Division
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Cellular Response To Thyroid Hormone Stimulus
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
Drugs
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
ABT-869
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Diseases
Piebaldism
Acute myeloid leukemia (AML)
GWAS
Prostate cancer (
23535732
)
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
29403010
28017375
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
29403010
28453575
28017375
)
Mean corpuscular volume (
29403010
28453575
20139978
28017375
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
32203549
31928498
)
Interacting Genes
24 interacting genes:
AATK
CARHSP1
EGFR
EPHA2
EPHA3
EPHA7
EPHB6
ERBB2
ERBB3
ERBB4
FBXO7
FBXW7
IGF1R
INSR
INSRR
KDR
KIT
LMTK2
MAPK1
MUSK
PTK7
ROR1
ROR2
TEK
92 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
Entrez ID
6815
3815
HPRD ID
10258
01287
Ensembl ID
ENSG00000198252
ENSG00000157404
Uniprot IDs
A0A024R641
Q8WUJ0
A0A0U2N547
P10721
PDB IDs
2R0B
1PKG
1QZJ
1QZK
1R01
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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