INSRR and KRT27

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		INSRR	KRT27
Description		insulin receptor related receptor	keratin 27
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Insulin Receptor Complex Axon Receptor Complex	Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding Insulin Receptor Substrate Binding	Molecular_function Structural Molecule Activity Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Male Sex Determination Actin Cytoskeleton Reorganization Positive Regulation Of Kinase Activity Protein Autophosphorylation Cellular Response To Alkaline PH	Biological_process Hair Follicle Morphogenesis Keratinization Cornification
Pathways			Keratinization Formation of the cornified envelope
Drugs		Fostamatinib
Diseases
GWAS		Uric acid clearance ( 28095793)	Asthma ( 31959851)
Interacting Genes		6 interacting genes: CTDSP2 ERBB2 INSR KRT27 MEOX2 STYX	145 interacting genes: AARD ABI2 AMOT ARFIP1 ARHGEF6 ATP6V1D BCAS2 BEX2 BFSP1 BFSP2 C19orf44 C1orf216 C21orf58 CCBE1 CCDC138 CCDC146 CCDC185 CCDC187 CCDC22 CCDC68 CCHCR1 CCNC CEP95 CFAP58 COX5B DPPA3 DTNB DUSP26 EXOC3L1 EXOSC5 FAM107A FAM110A FMNL2 GADD45GIP1 GAS8 GFAP GNG13 GOLGA1 GPS2 GSTK1 HAPLN2 HDAC4 HGS HOOK3 HOXB9 HSPBP1 ICA1L IGF1R INSR INSRR JOSD1 KANK2 KIAA1217 KLHL38 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LKAAEAR1 LMNTD2 MATR3 MBD3L2 MID2 MORN4 MOS MTMR9 NDC80 NDUFAF3 NTAQ1 NUP54 NUP58 ODAD3 OIP5 PBX3 PCDHB14 PNN POLL PPP1R18 PRPH PSMC5 RASAL3 RBM41 RCOR3 RNF39 RTP5 RUNX1T1 SCNM1 SDHAF1 SEMA4C SGF29 SLC22A5 SLIRP SMARCC2 SMARCD1 SMARCE1 SNAPIN SSC5D SSX3 SUFU SUOX TBRG4 TEAD4 TEDC2 TEX28 THAP7 TNNT1 TRAF3IP3 TRIML2 TSKS TTC23 TXLNA TXLNB TXN2 USHBP1 USP2 VPS37C WASHC3 XRCC4 ZC3H14 ZFYVE26 ZNF3 ZNF580 ZNF581 ZNF669 ZNF80
Entrez ID		3645	342574
HPRD ID		00976	17244
Ensembl ID		ENSG00000027644	ENSG00000171446
Uniprot IDs		P14616	Q7Z3Y8
PDB IDs
Enriched GO Terms of Interacting Partners?
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