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STYX and TEK
Data Source:
BioGRID
(two hybrid)
STYX
TEK
Description
serine/threonine/tyrosine interacting protein
TEK receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Stress Fiber
Extracellular Region
Cytoplasm
Actin Filament
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
Cell-cell Junction
Focal Adhesion
Basal Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Apical Plasma Membrane
Centriolar Satellite
Receptor Complex
Membrane Raft
Molecular Function
Pseudophosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
F-box Domain Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Growth Factor Binding
Signaling Receptor Activity
Identical Protein Binding
Biological Process
Protein Dephosphorylation
Negative Regulation Of Protein Binding
Negative Regulation Of Catalytic Activity
MAPK Export From Nucleus
Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process
Regulation Of ERK1 And ERK2 Cascade
MAPK Cascade
Angiogenesis
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Endochondral Ossification
Sprouting Angiogenesis
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Multicellular Organism Development
Heart Development
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Regulation Of Establishment Or Maintenance Of Cell Polarity
Positive Regulation Of Kinase Activity
Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Tie Signaling Pathway
Negative Regulation Of Inflammatory Response
Leukocyte Migration
Response To CAMP
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Definitive Hemopoiesis
Heart Trabecula Formation
Positive Regulation Of ERK1 And ERK2 Cascade
Glomerulus Vasculature Development
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Tie2 Signaling
Tie2 Signaling
RAF/MAP kinase cascade
Drugs
Ampicillin
Vandetanib
N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE
Regorafenib
Ponatinib
Fostamatinib
Ripretinib
Diseases
Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS
Prostate cancer (
23535732
)
Adult asthma (
27611488
)
Age-related cognitive decline (attention/processing speed) (slope of z-scores) (
30954325
)
Asthma (
27611488
)
Blood protein levels (
30072576
29875488
28240269
)
Blood protein levels in cardiovascular risk (
28369058
)
Cognitive decline (age-related) (
28078323
)
Coronary artery disease (
29212778
)
Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) (
33208821
)
Interacting Genes
24 interacting genes:
AATK
CARHSP1
EGFR
EPHA2
EPHA3
EPHA7
EPHB6
ERBB2
ERBB3
ERBB4
FBXO7
FBXW7
IGF1R
INSR
INSRR
KDR
KIT
LMTK2
MAPK1
MUSK
PTK7
ROR1
ROR2
TEK
25 interacting genes:
ANGPT1
ANGPT2
ANGPT4
ANGPTL1
APP
CAV1
DOK2
DOK4
DUSP18
GRB14
GRB2
GRB7
IKBKG
ILKAP
PIK3R1
PTPN11
PTPRB
PTPRR
SHC1
SOCS1
STAT5A
STAT5B
STYX
TIE1
TNIP2
Entrez ID
6815
7010
HPRD ID
10258
02571
Ensembl ID
ENSG00000198252
ENSG00000120156
Uniprot IDs
A0A024R641
Q8WUJ0
Q02763
Q59HG2
PDB IDs
2R0B
1FVR
2GY5
2GY7
2OO8
2OSC
2P4I
2WQB
3BEA
3L8P
4K0V
4X3J
5MYA
5MYB
5UTK
6MWE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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