RXRA and ARNTL

Data Source:
BioGRID (pull down)

		RXRA	ARNTL
Description		retinoid X receptor alpha	aryl hydrocarbon receptor nuclear translocator like
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Receptor Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex PML Body Chromatoid Body Aryl Hydrocarbon Receptor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Enzyme Binding Peptide Binding Identical Protein Binding Vitamin D Receptor Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding DNA Binding Domain Binding LBD Domain Binding Vitamin D Response Element Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Aryl Hydrocarbon Receptor Binding Sequence-specific DNA Binding Protein Dimerization Activity Hsp90 Protein Binding E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cholesterol Metabolic Process Bile Acid And Bile Salt Transport Modulation By Virus Of Host Process Regulation Of Lipid Metabolic Process Cell Differentiation Response To Retinoic Acid Peroxisome Proliferator Activated Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Acetylation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression Circadian Clock
Drugs		alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Blood pressure ( 24954895) Central corneal thickness ( 28171582 22814818 31798171 23493294 29760442 30894546) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Intelligence ( 22449649) Intraocular pressure ( 29617998) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Adult body size ( 32376654) Body mass index ( 25673413) C-reactive protein levels ( 30388399) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Cooked vegetable consumption ( 32066663) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 27618448 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Face memory ( 31596458) Feeling guilty ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (transferrin levels) ( 25352340) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Neurociticism ( 29500382) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Psoriasis ( 30921485) Red blood cell count ( 32888494) Schizophrenia ( 23358160) Systolic blood pressure ( 31928498) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Triglyceride levels ( 32203549 32154731 31928498 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		118 interacting genes: ACVR1 ACVR1B ALOX15B ARID5A ARNTL BCL3 BRD8 CASP2 CHD9 CLOCK CNOT1 COPS2 CSNK2B CTCF CTNNB1 CTSL DNMT3L DNTTIP2 EDF1 ESR1 ESRRA FUS GADD45A GADD45G GATA2 GK GRIP1 GSK3B HDAC3 HDAC4 HMGA1 IGFBP3 ITGB3BP JAZF1 JMJD1C KIF1A KLF5 MAPK1 MAPK3 MAPK7 MECR MED1 MED24 MED25 MPG MYOD1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFKB1 NFKBIB NPAS2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2E3 NR2F1 NR2F6 NR3C2 NR4A1 NR4A2 NRBF2 NRIP1 NSD1 PARP1 PLK1 PML POU2F1 POU2F2 PPARA PPARD PPARG PPARGC1A PRKD2 PRMT2 PSMC3IP PSMC5 RAD54L2 RARA RARB RARG RELA RNF8 ROBO4 RPS6KA6 SMAD2 SMARCB1 SMARCD3 SMN1 SNW1 SP1 SRC SRF STAT1 TADA3 TAF11 TAF1B TBP TDG THRA THRB TK1 TMPRSS3 TRIM24 TRIP10 TRIP4 UBE2I UBQLN4 VDR ZBTB16 ZNHIT3	25 interacting genes: AHR AZIN1 BHLHE40 CLOCK CRY1 CSNK1E DELEC1 DHTKD1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 TRAPPC12 UBE2I ZMYND12
Entrez ID		6256	406
HPRD ID		01577	03973
Ensembl ID		ENSG00000186350	ENSG00000133794
Uniprot IDs		A0A5F9ZHH6 F1D8Q5 P19793 Q6P3U7	A0A140VKD3 A0A669KBF4 B2RCL8 O00327
PDB IDs		1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6JNO 6JNR 6L6K 6SJM 6STI 6XWG 6XWH 7A77	4H10
Enriched GO Terms of Interacting Partners?
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