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PRMT1 and MIR222
Data Source:
BioGRID
(unspecified method)
PRMT1
MIR222
Description
protein arginine methyltransferase 1
microRNA 222
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Methylosome
Extracellular Space
Extracellular Vesicle
Molecular Function
RNA Binding
Protein Binding
Methyltransferase Activity
N-methyltransferase Activity
Protein Methyltransferase Activity
Methyl-CpG Binding
Protein-arginine N-methyltransferase Activity
Enzyme Binding
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Identical Protein Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Mitogen-activated Protein Kinase P38 Binding
S-adenosyl-L-methionine Binding
MRNA Binding Involved In Posttranscriptional Gene Silencing
Biological Process
In Utero Embryonic Development
Protein Methylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Histone Methylation
Peptidyl-arginine Methylation
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Neuron Projection Development
Histone H4-R3 Methylation
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Hemoglobin Biosynthetic Process
Protein Homooligomerization
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Negative Regulation Of Interleukin-21 Production
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Apoptotic Process
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Axon Regeneration
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Cell Proliferation
Negative Regulation Of Cell Adhesion Molecule Production
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Schwann Cell Migration
Negative Regulation Of Hematopoietic Stem Cell Proliferation
Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
RMTs methylate histone arginines
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Drugs
S-adenosyl-L-homocysteine
Diseases
GWAS
Schizophrenia (
29483656
)
Interacting Genes
151 interacting genes:
AR
ARPC3
ASH2L
AXIN1
BRCA1
BTG1
BTG2
C4orf17
CAPRIN1
CDC37
CEP162
CIRBP
CNOT8
COIL
DAXX
DCAF16
DCAF8
DHX9
EIF4A1
EP300
ESR1
EWSR1
FAM83D
FAM9A
FBL
FBXL17
FBXO7
FGF2
FLII
FUS
GLI1
GPATCH2L
GRHL3
GRIP1
H3C1
H4-16
H4C14
HABP4
HNF4A
HNRNPA1
HNRNPK
HNRNPR
HNRNPU
HNRNPUL1
HROB
IDH3B
IFNAR1
IGSF21
ILF3
KHDRBS1
KHDRBS2
KHDRBS3
LRIF1
MBP
MECOM
MED31
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR138-1
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR206
MIR20A
MIR20B
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR34A
MIR34C
MIR363
MIR451A
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MLST8
NCOA1
NCOA2
NCOA3
NOL4
NRIP1
NTAQ1
OFCC1
PPARA
PRMT8
QKI
RBM15
RELA
RNF187
RUNX1
S100A8
SAMD3
SHLD1
SIRT1
SPAG8
SPEG
SPSB1
SPSB2
STAT1
STAT5A
STUB1
SUPT5H
TBX6
TERF2
THRB
TP53
TRIM48
UBE4B
VHL
VPS72
WDFY3
WDR33
YLPM1
YWHAG
ZBTB14
ZMYM5
ZNF451
75 interacting genes:
ADARB1
AIMP1
AIMP2
APOBEC3B
AQR
C1QBP
DARS1
DDX1
DDX21
DDX3X
DHX36
EDC4
EIF2AK2
EPRS1
ESRP1
FAM98A
FAM98B
FUS
G3BP2
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IGF2BP1
IGF2BP2
IGF2BP3
KNOP1
LARP7
LIN28A
LRPPRC
MATR3
MSI2
NONO
PDCD11
PLOD1
PRMT1
PTBP1
PTBP3
PUF60
PURA
QARS1
RBFOX2
RBM14
RBM4
RBMS2
RTCA
RTCB
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
SUGP2
SYNCRIP
TAF15
TENT2
TRA2A
TRA2B
U2SURP
UPF1
UTP20
YBX1
YBX2
YBX3
ZFR
ZNF346
Entrez ID
3276
407007
HPRD ID
04257
Ensembl ID
ENSG00000126457
ENSG00000207725
Uniprot IDs
Q99873
PDB IDs
6NT2
Enriched GO Terms of Interacting Partners
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