SSTR4 and SST

Data Source:
HPRD (in vivo)

		SSTR4	SST
Description		somatostatin receptor 4	somatostatin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Extracellular Region Extracellular Space Neuronal Cell Body Synapse
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Peptide Binding Neuropeptide Binding	Hormone Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Migration Forebrain Development Somatostatin Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Response To Acidic PH Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates transcription of neuronal ligands
Drugs		Somatostatin Lutetium Lu 177 dotatate
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood sugar levels ( 29403010) Hypothyroidism ( 27182965) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Vitamin D levels ( 26704534)	Pursuit maintenance gain ( 29064472) Skin pigmentation ( 28300201)
Interacting Genes		2 interacting genes: CORT SST	6 interacting genes: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6754	6750
HPRD ID		01676	08920
Ensembl ID		ENSG00000132671	ENSG00000157005
Uniprot IDs		P31391	P61278
PDB IDs			1P2W 2MI1
Enriched GO Terms of Interacting Partners?
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