SST and SSTR4

Data Source:
HPRD (in vivo)

		SST	SSTR4
Description		somatostatin	somatostatin receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body Synapse	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	Hormone Activity Protein Binding	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Response To Acidic PH Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Migration Forebrain Development Somatostatin Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates transcription of neuronal ligands	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Somatostatin Lutetium Lu 177 dotatate
Diseases
GWAS		Pursuit maintenance gain ( 29064472) Skin pigmentation ( 28300201)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood sugar levels ( 29403010) Hypothyroidism ( 27182965) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Vitamin D levels ( 26704534)
Interacting Genes		6 interacting genes: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	2 interacting genes: CORT SST
Entrez ID		6750	6754
HPRD ID		08920	01676
Ensembl ID		ENSG00000157005	ENSG00000132671
Uniprot IDs		P61278	P31391
PDB IDs		1P2W 2MI1
Enriched GO Terms of Interacting Partners?
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