SPTA1 and FANCC

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		SPTA1	FANCC
Description		spectrin alpha, erythrocytic 1	FA complementation group C
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding	Protein Binding
	Biological Process	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Germ Cell Development Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Interstrand Cross-link Repair Brain Morphogenesis Protein-containing Complex Assembly Neuronal Stem Cell Population Maintenance
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)	Fanconi anemia
GWAS		Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) Platelet distribution width ( 32888494) QRS duration ( 27577874) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)	Birth weight ( 31043758) Hematocrit ( 32888494) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 26284813)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 ODF3B PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326	54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32
Entrez ID		6708	2176
HPRD ID		01685	01967
Ensembl ID		ENSG00000163554	ENSG00000158169
Uniprot IDs		P02549	A0A024R9N2 A0A087WW44 B4E3W2 Q00597
PDB IDs		1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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