SPTA1 and ZNF326

Data Source:
BioGRID (two hybrid)

		SPTA1	ZNF326
Description		spectrin alpha, erythrocytic 1	zinc finger protein 326
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Nucleus Nucleoplasm Nuclear Matrix Intracellular Membrane-bounded Organelle DBIRD Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding	RNA Polymerase II Complex Binding DNA Binding RNA Binding Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	MRNA Processing RNA Splicing Regulation Of DNA-templated Transcription, Elongation Regulation Of RNA Splicing
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) Platelet distribution width ( 32888494) QRS duration ( 27577874) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)	Brain structure (hippocampal volume) ( 20197096) Major depressive disorder ( 27479909) Obsessive-compulsive symptoms ( 26859814) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 ODF3B PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326	8 interacting genes: GEMIN4 GYS1 KHDRBS3 KPNA5 NCOA5 PTEN SPTA1 VMAC
Entrez ID		6708	284695
HPRD ID		01685	15774
Ensembl ID		ENSG00000163554	ENSG00000162664
Uniprot IDs		P02549	A0A0A0MRN4 Q5BKZ1
PDB IDs		1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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