SPTA1 and EVL

Data Source:
HPRD (two hybrid)

		SPTA1	EVL
Description		spectrin alpha, erythrocytic 1	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) Platelet distribution width ( 32888494) QRS duration ( 27577874) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 ODF3B PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326	33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		6708	51466
HPRD ID		01685	10942
Ensembl ID		ENSG00000163554	ENSG00000196405
Uniprot IDs		P02549	A0A024R6K5 Q9UI08
PDB IDs		1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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