SMPD2 and COQ8A

Data Source:
BioGRID (two hybrid)

		SMPD2	COQ8A
Description		sphingomyelin phosphodiesterase 2	coenzyme Q8A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery	Mitochondrion Integral Component Of Membrane Extrinsic Component Of Mitochondrial Inner Membrane
	Molecular Function	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity ADP Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process Positive Regulation Of Ceramide Biosynthetic Process	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation
Pathways		Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production
Drugs			Fostamatinib
Diseases			Coenzyme Q10 deficiency Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Height ( 18391951)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	26 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM159 TMEM239 TPD52L2
Entrez ID		6610	56997
HPRD ID		04608	07375
Ensembl ID		ENSG00000135587	ENSG00000163050
Uniprot IDs		O60906	Q8NI60
PDB IDs			4PED 5I35
Enriched GO Terms of Interacting Partners?
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