SMPD2 and PGRMC2

Data Source:
BioGRID (two hybrid)

		SMPD2	PGRMC2
Description		sphingomyelin phosphodiesterase 2	progesterone receptor membrane component 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery	Nuclear Envelope Endoplasmic Reticulum Endomembrane System Membrane Integral Component Of Membrane
	Molecular Function	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding	Steroid Hormone Receptor Activity Steroid Binding Protein Binding Heme Transmembrane Transporter Activity Heme Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process Positive Regulation Of Ceramide Biosynthetic Process	Heme Transport Steroid Hormone Mediated Signaling Pathway Adipose Tissue Development
Pathways		Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production
Drugs
Diseases
GWAS		Height ( 18391951)	Bone mineral density (total hip) ( 29883787)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	57 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LPAR3 MALL MFHAS1 MFSD5 ORMDL1 PEDS1-UBE2V1 PEX16 PGRMC1 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VAPA VEZT YIPF2 ZDHHC21 ZFPL1
Entrez ID		6610	10424
HPRD ID		04608	09665
Ensembl ID		ENSG00000135587	ENSG00000164040
Uniprot IDs		O60906	O15173
PDB IDs
Enriched GO Terms of Interacting Partners?
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