PLEKHA3 and SH2B2

Data Source:
BioGRID (two hybrid)

		PLEKHA3	SH2B2
Description		pleckstrin homology domain containing A3	SH2B adaptor protein 2
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Biological_process Ceramide Transport Intermembrane Lipid Transfer Ceramide 1-phosphate Transport	Blood Coagulation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)	Type 2 diabetes ( 31049640)
Interacting Genes		8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B	42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417
Entrez ID		65977	10603
HPRD ID		09688	16097
Ensembl ID		ENSG00000116095	ENSG00000160999
Uniprot IDs		Q9HB20	O14492
PDB IDs		2KCJ 2MDX 3RCP	1Q2H
Enriched GO Terms of Interacting Partners?
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